American Airlines flights from Des Moines to Mexico

Popular flights with American Airlines

$
keyboard_arrow_down

  • Des Moines (DSM)to

    Cancun (CUN)
    07/02/25 - 07/09/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/23/25 - 07/30/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    06/24/25 - 07/01/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/16/25 - 07/23/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Cancun (CUN)
    07/08/25 - 07/15/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/09/25 - 07/16/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/15/25 - 07/22/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/22/25 - 07/29/25
    from
    $454Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Cancun (CUN)
    07/30/25 - 08/06/25
    from
    $468Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/29/25 - 08/05/25
    from
    $468Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/10/25 - 07/17/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/24/25 - 07/31/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

  • Des Moines (DSM)to

    Cancun (CUN)
    06/26/25 - 07/03/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    06/09/25 - 06/16/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/03/25 - 07/10/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

    Des Moines (DSM)to

    Cancun (CUN)
    07/04/25 - 07/11/25
    from
    $476Fare subject to changes
    Updated: 16 hours ago
    Round trip
    I
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights from Des Moines to Mexico

Find more Des Moines to Mexico deals

$
keyboard_arrow_down

Des Moines (DSM)to

Cancun (CUN)
07/08/25 - 07/15/25

Round trip

I

Economy

from
$454Fare subject to changes
Updated: 16 hours ago

Des Moines (DSM)to

Puerto Vallarta (PVR)
07/22/25 - 07/29/25

Round trip

I

Economy

from
$496Fare subject to changes
Updated: 3 hours ago

Des Moines (DSM)to

Cabo San Lucas (SJD)
06/24/25 - 07/01/25

Round trip

I

Economy

from
$512Fare subject to changes
Updated: 12 hours ago

Des Moines (DSM)to

Mexico City (MEX)
06/25/25 - 07/02/25

Round trip

I

Economy

from
$538Fare subject to changes
Updated: 2 hours ago

Des Moines (DSM)to

Guadalajara (GDL)
07/01/25 - 07/08/25

Round trip

I

Economy

from
$536Fare subject to changes
Updated: 10 minutes ago

Des Moines (DSM)to

Cozumel (CZM)
09/03/25 - 09/10/25

Round trip

I

Economy

from
$494Fare subject to changes
Updated: 13 minutes ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Related flights

Explore American Airlines's Top-Pick Destinations