American Airlines flights from Des Moines to Mexico

Popular flights with American Airlines

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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights from Des Moines to Mexico

Find more Des Moines to Mexico deals

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Des Moines (DSM)to

Cancun (CUN)
10/07/25 - 10/14/25

Round trip

Economy

from
$404Fare subject to changes
Updated: 5 hours ago

Des Moines (DSM)to

Cabo San Lucas (SJD)
09/02/25 - 09/09/25

Round trip

Economy

from
$330Fare subject to changes
Updated: 2 hours ago

Des Moines (DSM)to

Cozumel (CZM)
11/04/25 - 11/11/25

Round trip

Economy

from
$497Fare subject to changes
Updated: 8 hours ago

Des Moines (DSM)to

Puerto Vallarta (PVR)
11/04/25 - 11/11/25

Round trip

Economy

from
$500Fare subject to changes
Updated: 11 hours ago

Des Moines (DSM)to

Mexico City (MEX)
09/02/25 - 09/09/25

Round trip

Economy

from
$541Fare subject to changes
Updated: 6 hours ago

Des Moines (DSM)to

Guadalajara (GDL)
08/22/25 - 08/29/25

Round trip

Economy

from
$539Fare subject to changes
Updated: 8 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.