American Airlines flights from Des Moines to Mexico City

Recent searches for flights from Des Moines to Mexico City

Sep 2026
From$682*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$637*
Updated: 1 hour ago
Round tripIEconomy
Nov 2026
From$637*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $637
cmp-daily-histogram-bars-legend-max-price-aria-label $901
Displaying fares for September-2026
  • DSM–MEX, 09/03/26 – 09/10/26: From $901
    03

    Th

    SEP

  • DSM–MEX, 09/04/26 – 09/11/26: From $785
    04

    Fr

  • DSM–MEX, 09/05/26 – 09/12/26: From $815
    05

    Sa

  • DSM–MEX, 09/06/26 – 09/13/26: From $820
    06

    Su

  • DSM–MEX, 09/07/26 – 09/14/26: From $785
    07

    Mo

  • DSM–MEX, 09/08/26 – 09/15/26: From $755
    08

    Tu

  • DSM–MEX, 09/09/26 – 09/16/26: From $755
    09

    We

  • DSM–MEX, 09/10/26 – 09/17/26: From $755
    10

    Th

  • DSM–MEX, 09/11/26 – 09/18/26: From $779
    11

    Fr

  • DSM–MEX, 09/12/26 – 09/19/26: From $815
    12

    Sa

  • DSM–MEX, 09/13/26 – 09/20/26: From $820
    13

    Su

  • DSM–MEX, 09/14/26 – 09/21/26: From $785
    14

    Mo

  • DSM–MEX, 09/15/26 – 09/22/26: From $755
    15

    Tu

  • DSM–MEX, 09/16/26 – 09/23/26: From $768
    16

    We

  • DSM–MEX, 09/17/26 – 09/24/26: From $741
    17

    Th

  • DSM–MEX, 09/18/26 – 09/25/26: From $741
    18

    Fr

  • DSM–MEX, 09/19/26 – 09/26/26: From $801
    19

    Sa

  • DSM–MEX, 09/20/26 – 09/27/26: From $806
    20

    Su

  • DSM–MEX, 09/21/26 – 09/28/26: From $771
    21

    Mo

  • DSM–MEX, 09/22/26 – 09/29/26: From $741
    22

    Tu

  • DSM–MEX, 09/23/26 – 09/30/26: From $741
    23

    We

  • DSM–MEX, 09/24/26 – 10/01/26: From $682
    24

    Th

  • DSM–MEX, 09/25/26 – 10/02/26: From $712
    25

    Fr

  • DSM–MEX, 09/26/26 – 10/03/26: From $742
    26

    Sa

  • DSM–MEX, 09/27/26 – 10/04/26: From $747
    27

    Su

  • DSM–MEX, 09/28/26 – 10/05/26: From $712
    28

    Mo

  • DSM–MEX, 09/29/26 – 10/06/26: From $682
    29

    Tu

  • DSM–MEX, 09/30/26 – 10/07/26: From $682
    30

    We

  • DSM–MEX, 10/01/26 – 10/08/26: From $648
    01

    Th

    OCT

  • DSM–MEX, 10/02/26 – 10/09/26: From $637
    02

    Fr

    • range$637-$901

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Mexico City flights

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    Des Moines (DSM)to

    Mexico City (MEX)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    10/02/26 - 10/09/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    12/09/26 - 12/16/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    11/12/26 - 11/19/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    11/18/26 - 11/25/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    Des Moines (DSM)to

    Mexico City (MEX)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $637Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Mexico City

    Looking for lower fares on your trip from Des Moines to Mexico City? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Mexico City