American Airlines flights from Des Moines to Portland, OR

Recent searches for flights from Des Moines to Portland, OR

Sep 2026
From$355*
Updated: 5 hours ago
Round tripIEconomy
Oct 2026
From$355*
Updated: 5 hours ago
Round tripIEconomy
Nov 2026
From$355*
Updated: 21 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $355
cmp-daily-histogram-bars-legend-max-price-aria-label $1.0K
Displaying fares for September-2026
  • DSM–PDX, 09/03/26 – 09/10/26: From $1,012
    03

    Th

    SEP

  • DSM–PDX, 09/04/26 – 09/11/26: From $1,012
    04

    Fr

  • DSM–PDX, 09/05/26 – 09/12/26: From $967
    05

    Sa

  • DSM–PDX, 09/06/26 – 09/13/26: From $1,012
    06

    Su

  • DSM–PDX, 09/07/26 – 09/14/26: From $1,012
    07

    Mo

  • DSM–PDX, 09/08/26 – 09/15/26: From $939
    08

    Tu

  • DSM–PDX, 09/09/26 – 09/16/26: From $466
    09

    We

  • DSM–PDX, 09/10/26 – 09/17/26: From $466
    10

    Th

  • DSM–PDX, 09/11/26 – 09/18/26: From $466
    11

    Fr

  • DSM–PDX, 09/12/26 – 09/19/26: From $466
    12

    Sa

  • DSM–PDX, 09/13/26 – 09/20/26: From $797
    13

    Su

  • DSM–PDX, 09/14/26 – 09/21/26: From $795
    14

    Mo

  • DSM–PDX, 09/15/26 – 09/22/26: From $772
    15

    Tu

  • DSM–PDX, 09/16/26 – 09/23/26: From $466
    16

    We

  • DSM–PDX, 09/17/26 – 09/24/26: From $466
    17

    Th

  • DSM–PDX, 09/18/26 – 09/25/26: From $481
    18

    Fr

  • DSM–PDX, 09/19/26 – 09/26/26: From $466
    19

    Sa

  • DSM–PDX, 09/20/26 – 09/27/26: From $537
    20

    Su

  • DSM–PDX, 09/21/26 – 09/28/26: From $466
    21

    Mo

  • DSM–PDX, 09/22/26 – 09/29/26: From $466
    22

    Tu

  • DSM–PDX, 09/23/26 – 09/30/26: From $355
    23

    We

  • DSM–PDX, 09/24/26 – 10/01/26: From $355
    24

    Th

  • DSM–PDX, 09/25/26 – 10/02/26: From $385
    25

    Fr

  • DSM–PDX, 09/26/26 – 10/03/26: From $355
    26

    Sa

  • DSM–PDX, 09/27/26 – 10/04/26: From $517
    27

    Su

  • DSM–PDX, 09/28/26 – 10/05/26: From $355
    28

    Mo

  • DSM–PDX, 09/29/26 – 10/06/26: From $355
    29

    Tu

  • DSM–PDX, 09/30/26 – 10/07/26: From $355
    30

    We

  • DSM–PDX, 10/01/26 – 10/08/26: From $355
    01

    Th

    OCT

  • DSM–PDX: cmp-view-offers-disclaimer. Find Offers
    02

    Fr

    • range$355-$1,012

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Portland, OR flights

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    Des Moines (DSM)to

    Portland, OR (PDX)
    10/15/26 - 10/22/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    10/05/26 - 10/12/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    Portland, OR (PDX)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $355Fare subject to changes
    Updated: 5 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Portland, OR

    Looking for lower fares on your trip from Des Moines to Portland, OR? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Portland, OR