American Airlines flights from Key West to Detroit

Recent searches for flights from Key West to Detroit

Sep 2026
From$459*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$353*
Updated: 1 hour ago
Round tripIEconomy
Nov 2026
From$353*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $406
cmp-daily-histogram-bars-legend-max-price-aria-label $730
Displaying fares for September-2026
  • EYW–DTW, 09/12/26 – 09/19/26: From $523
    12

    Sa

    SEP

  • EYW–DTW, 09/13/26 – 09/20/26: From $693
    13

    Su

  • EYW–DTW, 09/14/26 – 09/21/26: From $613
    14

    Mo

  • EYW–DTW, 09/15/26 – 09/22/26: From $523
    15

    Tu

  • EYW–DTW, 09/16/26 – 09/23/26: From $459
    16

    We

  • EYW–DTW, 09/17/26 – 09/24/26: From $693
    17

    Th

  • EYW–DTW, 09/18/26 – 09/25/26: From $613
    18

    Fr

  • EYW–DTW, 09/19/26 – 09/26/26: From $459
    19

    Sa

  • EYW–DTW, 09/20/26 – 09/27/26: From $606
    20

    Su

  • EYW–DTW, 09/21/26 – 09/28/26: From $606
    21

    Mo

  • EYW–DTW, 09/22/26 – 09/29/26: From $523
    22

    Tu

  • EYW–DTW, 09/23/26 – 09/30/26: From $459
    23

    We

  • EYW–DTW, 09/24/26 – 10/01/26: From $693
    24

    Th

  • EYW–DTW, 09/25/26 – 10/02/26: From $730
    25

    Fr

  • EYW–DTW, 09/26/26 – 10/03/26: From $592
    26

    Sa

  • EYW–DTW, 09/27/26 – 10/04/26: From $720
    27

    Su

  • EYW–DTW, 09/28/26 – 10/05/26: From $663
    28

    Mo

  • EYW–DTW, 09/29/26 – 10/06/26: From $492
    29

    Tu

  • EYW–DTW, 09/30/26 – 10/07/26: From $459
    30

    We

  • EYW–DTW, 10/01/26 – 10/08/26: From $728
    01

    Th

    OCT

  • EYW–DTW, 10/02/26 – 10/09/26: From $728
    02

    Fr

  • EYW–DTW, 10/03/26 – 10/10/26: From $479
    03

    Sa

  • EYW–DTW, 10/04/26 – 10/11/26: From $621
    04

    Su

  • EYW–DTW, 10/05/26 – 10/12/26: From $536
    05

    Mo

  • EYW–DTW, 10/06/26 – 10/13/26: From $406
    06

    Tu

  • EYW–DTW, 10/07/26 – 10/14/26: From $406
    07

    We

  • EYW–DTW, 10/08/26 – 10/15/26: From $621
    08

    Th

  • EYW–DTW, 10/09/26 – 10/16/26: From $471
    09

    Fr

  • EYW–DTW: cmp-view-offers-disclaimer. Find Offers
    10

    Sa

  • EYW–DTW: cmp-view-offers-disclaimer. Find Offers
    11

    Su

    • range$406-$730

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Key West to Detroit flights

    $
    keyboard_arrow_down

    Key West (EYW)to

    Detroit (DTW)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    11/25/26 - 12/02/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    Key West (EYW)to

    Detroit (DTW)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $353Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Key West to Detroit

    Looking for lower fares on your trip from Key West to Detroit? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Key West to Detroit