American Airlines flights from Knoxville to Chicago

Recent searches for flights from Knoxville to Chicago

Mar 2026
From$389*
Updated: 1 hour ago
Round tripIEconomy
Apr 2026
From$229*
Updated: 2 hours ago
Round tripIEconomy
May 2026
From$229*
Updated: 2 hours ago
Round tripIEconomy
$244
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    • range$244-$542

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to Chicago flights

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    Knoxville (TYS)to

    Chicago (ORD)
    11/11/26 - 11/21/26

    Round trip

    Economy

    from
    $229Fare subject to changes
    Updated: 18 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    10/02/26 - 10/06/26

    Round trip

    Economy

    from
    $229Fare subject to changes
    Updated: 2 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    05/14/26 - 05/18/26

    Round trip

    Economy

    from
    $229Fare subject to changes
    Updated: 2 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    04/17/26 - 04/21/26

    Round trip

    Economy

    from
    $229Fare subject to changes
    Updated: 2 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    04/01/26 - 04/05/26

    Round trip

    Economy

    from
    $244Fare subject to changes
    Updated: 1 minute ago

    Knoxville (TYS)to

    Chicago (ORD)
    04/03/26 - 04/05/26

    Round trip

    Economy

    from
    $254Fare subject to changes
    Updated: 23 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    09/04/26 - 09/08/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 18 hours ago

    Knoxville (TYS)to

    Chicago (ORD)
    06/19/26 - 06/21/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 2 minutes ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    American Airlines flights from Knoxville to Chicago

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