American Airlines flights from Knoxville to New Orleans

Recent searches for flights from Knoxville to New Orleans

Aug 2026
From$493*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$287*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$287*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $287
cmp-daily-histogram-bars-legend-max-price-aria-label $670
Displaying fares for August-2026
  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    24

    Mo

    AUG

  • TYS–MSY, 08/25/26 – 09/01/26: From $493
    25

    Tu

  • TYS–MSY, 08/26/26 – 09/02/26: From $493
    26

    We

  • TYS–MSY, 08/27/26 – 09/03/26: From $629
    27

    Th

  • TYS–MSY, 08/28/26 – 09/04/26: From $629
    28

    Fr

  • TYS–MSY, 08/29/26 – 09/05/26: From $493
    29

    Sa

  • TYS–MSY, 08/30/26 – 09/06/26: From $629
    30

    Su

  • TYS–MSY, 08/31/26 – 09/07/26: From $670
    31

    Mo

  • TYS–MSY, 09/01/26 – 09/08/26: From $493
    01

    Tu

    SEP

  • TYS–MSY, 09/02/26 – 09/09/26: From $470
    02

    We

  • TYS–MSY, 09/03/26 – 09/10/26: From $578
    03

    Th

  • TYS–MSY, 09/04/26 – 09/11/26: From $578
    04

    Fr

  • TYS–MSY, 09/05/26 – 09/12/26: From $367
    05

    Sa

  • TYS–MSY, 09/06/26 – 09/13/26: From $367
    06

    Su

  • TYS–MSY, 09/07/26 – 09/14/26: From $498
    07

    Mo

  • TYS–MSY, 09/08/26 – 09/15/26: From $367
    08

    Tu

  • TYS–MSY, 09/09/26 – 09/16/26: From $295
    09

    We

  • TYS–MSY, 09/10/26 – 09/17/26: From $407
    10

    Th

  • TYS–MSY, 09/11/26 – 09/18/26: From $353
    11

    Fr

  • TYS–MSY, 09/12/26 – 09/19/26: From $287
    12

    Sa

  • TYS–MSY, 09/13/26 – 09/20/26: From $487
    13

    Su

  • TYS–MSY, 09/14/26 – 09/21/26: From $353
    14

    Mo

  • TYS–MSY, 09/15/26 – 09/22/26: From $287
    15

    Tu

  • TYS–MSY, 09/16/26 – 09/23/26: From $287
    16

    We

  • TYS–MSY, 09/17/26 – 09/24/26: From $498
    17

    Th

  • TYS–MSY, 09/18/26 – 09/20/26: From $420
    18

    Fr

  • TYS–MSY, 09/19/26 – 09/26/26: From $287
    19

    Sa

  • TYS–MSY, 09/20/26 – 09/27/26: From $598
    20

    Su

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    21

    Mo

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    22

    Tu

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    23

    We

    • range$287-$670

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to New Orleans flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    New Orleans (MSY)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    New Orleans (MSY)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to New Orleans

    Looking for lower fares on your trip from Knoxville to New Orleans? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to New Orleans