American Airlines flights from Knoxville to Santa Fe

Recent searches for flights from Knoxville to Santa Fe

Sep 2026
From$337*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$337*
Updated: 8 hours ago
Round tripIEconomy
Nov 2026
From$337*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $337
cmp-daily-histogram-bars-legend-max-price-aria-label $1.1K
Displaying fares for September-2026
  • TYS–SAF: cmp-view-offers-disclaimer. Find Offers
    01

    Tu

    SEP

  • TYS–SAF, 09/02/26 – 09/09/26: From $499
    02

    We

  • TYS–SAF, 09/03/26 – 09/10/26: From $507
    03

    Th

  • TYS–SAF, 09/04/26 – 09/11/26: From $548
    04

    Fr

  • TYS–SAF, 09/05/26 – 09/12/26: From $499
    05

    Sa

  • TYS–SAF, 09/06/26 – 09/13/26: From $1,009
    06

    Su

  • TYS–SAF, 09/07/26 – 09/14/26: From $469
    07

    Mo

  • TYS–SAF, 09/08/26 – 09/15/26: From $472
    08

    Tu

  • TYS–SAF, 09/09/26 – 09/16/26: From $430
    09

    We

  • TYS–SAF, 09/10/26 – 09/17/26: From $612
    10

    Th

  • TYS–SAF, 09/11/26 – 09/18/26: From $729
    11

    Fr

  • TYS–SAF, 09/12/26 – 09/19/26: From $487
    12

    Sa

  • TYS–SAF, 09/13/26 – 09/20/26: From $790
    13

    Su

  • TYS–SAF, 09/14/26 – 09/21/26: From $442
    14

    Mo

  • TYS–SAF, 09/15/26 – 09/22/26: From $372
    15

    Tu

  • TYS–SAF, 09/16/26 – 09/23/26: From $505
    16

    We

  • TYS–SAF, 09/17/26 – 09/24/26: From $722
    17

    Th

  • TYS–SAF, 09/18/26 – 09/25/26: From $680
    18

    Fr

  • TYS–SAF, 09/19/26 – 09/26/26: From $464
    19

    Sa

  • TYS–SAF, 09/20/26 – 10/02/26: From $679
    20

    Su

  • TYS–SAF, 09/21/26 – 09/28/26: From $619
    21

    Mo

  • TYS–SAF, 09/22/26 – 09/29/26: From $337
    22

    Tu

  • TYS–SAF, 09/23/26 – 09/30/26: From $372
    23

    We

  • TYS–SAF, 09/24/26 – 10/01/26: From $654
    24

    Th

  • TYS–SAF, 09/25/26 – 10/02/26: From $513
    25

    Fr

  • TYS–SAF, 09/26/26 – 10/03/26: From $337
    26

    Sa

  • TYS–SAF, 09/27/26 – 10/04/26: From $1,120
    27

    Su

  • TYS–SAF, 09/28/26 – 10/05/26: From $681
    28

    Mo

  • TYS–SAF: cmp-view-offers-disclaimer. Find Offers
    29

    Tu

  • TYS–SAF: cmp-view-offers-disclaimer. Find Offers
    30

    We

    • range$337-$1,120

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to Santa Fe flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    Santa Fe (SAF)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    11/25/26 - 12/02/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    Knoxville (TYS)to

    Santa Fe (SAF)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $337Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to Santa Fe

    Looking for lower fares on your trip from Knoxville to Santa Fe? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to Santa Fe