American Airlines flights from Columbus to Panama City

Recent searches for flights from Columbus to Panama City

Sep 2026
From$384*
Updated: 17 hours ago
Round tripIEconomy
Oct 2026
From$359*
Updated: 17 hours ago
Round tripIEconomy
Nov 2026
From$359*
Updated: 17 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $384
cmp-daily-histogram-bars-legend-max-price-aria-label $699
Displaying fares for September-2026
  • CMH–ECP: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

    SEP

  • CMH–ECP, 09/05/26 – 09/12/26: From $447
    05

    Sa

  • CMH–ECP, 09/06/26 – 09/13/26: From $590
    06

    Su

  • CMH–ECP, 09/07/26 – 09/14/26: From $478
    07

    Mo

  • CMH–ECP, 09/08/26 – 09/15/26: From $409
    08

    Tu

  • CMH–ECP, 09/09/26 – 09/16/26: From $470
    09

    We

  • CMH–ECP, 09/10/26 – 09/17/26: From $699
    10

    Th

  • CMH–ECP, 09/11/26 – 09/18/26: From $558
    11

    Fr

  • CMH–ECP, 09/12/26 – 09/19/26: From $473
    12

    Sa

  • CMH–ECP, 09/13/26 – 09/20/26: From $590
    13

    Su

  • CMH–ECP, 09/14/26 – 09/21/26: From $553
    14

    Mo

  • CMH–ECP, 09/15/26 – 09/22/26: From $409
    15

    Tu

  • CMH–ECP, 09/16/26 – 09/23/26: From $492
    16

    We

  • CMH–ECP, 09/17/26 – 09/24/26: From $553
    17

    Th

  • CMH–ECP, 09/18/26 – 09/25/26: From $573
    18

    Fr

  • CMH–ECP, 09/19/26 – 09/26/26: From $447
    19

    Sa

  • CMH–ECP, 09/20/26 – 09/27/26: From $657
    20

    Su

  • CMH–ECP, 09/21/26 – 09/28/26: From $600
    21

    Mo

  • CMH–ECP, 09/22/26 – 09/29/26: From $433
    22

    Tu

  • CMH–ECP, 09/23/26 – 09/30/26: From $433
    23

    We

  • CMH–ECP, 09/24/26 – 10/01/26: From $595
    24

    Th

  • CMH–ECP, 09/25/26 – 10/02/26: From $450
    25

    Fr

  • CMH–ECP, 09/26/26 – 10/03/26: From $433
    26

    Sa

  • CMH–ECP, 09/27/26 – 10/04/26: From $590
    27

    Su

  • CMH–ECP, 09/28/26 – 10/05/26: From $393
    28

    Mo

  • CMH–ECP, 09/29/26 – 10/06/26: From $384
    29

    Tu

  • CMH–ECP, 09/30/26 – 10/07/26: From $384
    30

    We

  • CMH–ECP, 10/01/26 – 10/08/26: From $533
    01

    Th

    OCT

  • CMH–ECP: cmp-view-offers-disclaimer. Find Offers
    02

    Fr

  • CMH–ECP: cmp-view-offers-disclaimer. Find Offers
    03

    Sa

    • range$384-$699

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Columbus to Panama City flights

    $
    keyboard_arrow_down

    Columbus (CMH)to

    Panama City (ECP)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    Columbus (CMH)to

    Panama City (ECP)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 17 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Columbus to Panama City

    Looking for lower fares on your trip from Columbus to Panama City? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Columbus to Panama City