American Airlines flights from Detroit to Panama City

Recent searches for flights from Detroit to Panama City

Mar 2026
From$722*
Updated: 5 hours ago
Round tripIEconomy
Apr 2026
From$515*
Updated: 5 hours ago
Round tripIEconomy
May 2026
From$520*
Updated: 5 hours ago
Round tripIEconomy
$584
$1.4K
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    • range$584-$1,371

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Panama City flights

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    Detroit (DTW)to

    Panama City (ECP)
    04/14/26 - 04/21/26

    Round trip

    Economy

    from
    $515Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    05/05/26 - 05/12/26

    Round trip

    Economy

    from
    $520Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    04/28/26 - 05/05/26

    Round trip

    Economy

    from
    $520Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    05/13/26 - 05/20/26

    Round trip

    Economy

    from
    $560Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    04/21/26 - 04/28/26

    Round trip

    Economy

    from
    $560Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    05/02/26 - 05/09/26

    Round trip

    Economy

    from
    $565Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    04/07/26 - 04/14/26

    Round trip

    Economy

    from
    $584Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    04/08/26 - 04/15/26

    Round trip

    Economy

    from
    $584Fare subject to changes
    Updated: 5 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    American Airlines flights from Detroit to Panama City

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