American Airlines flights from Detroit to Panama City

Recent searches for flights from Detroit to Panama City

Aug 2026
From$505*
Updated: 5 hours ago
Round tripIEconomy
Sep 2026
From$313*
Updated: 5 hours ago
Round tripIEconomy
Oct 2026
From$313*
Updated: 5 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $319
cmp-daily-histogram-bars-legend-max-price-aria-label $793
Displaying fares for August-2026
  • DTW–ECP, 08/27/26 – 09/03/26: From $571
    27

    Th

    AUG

  • DTW–ECP, 08/28/26 – 09/04/26: From $571
    28

    Fr

  • DTW–ECP, 08/29/26 – 09/05/26: From $505
    29

    Sa

  • DTW–ECP, 08/30/26 – 09/06/26: From $571
    30

    Su

  • DTW–ECP, 08/31/26 – 09/07/26: From $793
    31

    Mo

  • DTW–ECP, 09/01/26 – 09/08/26: From $574
    01

    Tu

    SEP

  • DTW–ECP, 09/02/26 – 09/09/26: From $501
    02

    We

  • DTW–ECP, 09/03/26 – 09/10/26: From $662
    03

    Th

  • DTW–ECP, 09/04/26 – 09/11/26: From $571
    04

    Fr

  • DTW–ECP, 09/05/26 – 09/12/26: From $405
    05

    Sa

  • DTW–ECP, 09/06/26 – 09/13/26: From $405
    06

    Su

  • DTW–ECP, 09/07/26 – 09/14/26: From $571
    07

    Mo

  • DTW–ECP, 09/08/26 – 09/15/26: From $501
    08

    Tu

  • DTW–ECP, 09/09/26 – 09/16/26: From $411
    09

    We

  • DTW–ECP, 09/10/26 – 09/17/26: From $591
    10

    Th

  • DTW–ECP, 09/11/26 – 09/18/26: From $481
    11

    Fr

  • DTW–ECP, 09/12/26 – 09/19/26: From $485
    12

    Sa

  • DTW–ECP, 09/13/26 – 09/20/26: From $581
    13

    Su

  • DTW–ECP, 09/14/26 – 09/21/26: From $571
    14

    Mo

  • DTW–ECP, 09/15/26 – 09/22/26: From $411
    15

    Tu

  • DTW–ECP, 09/16/26 – 09/23/26: From $415
    16

    We

  • DTW–ECP, 09/17/26 – 09/24/26: From $662
    17

    Th

  • DTW–ECP, 09/18/26 – 09/25/26: From $590
    18

    Fr

  • DTW–ECP, 09/19/26 – 09/26/26: From $460
    19

    Sa

  • DTW–ECP, 09/20/26 – 09/27/26: From $442
    20

    Su

  • DTW–ECP, 09/21/26 – 09/28/26: From $386
    21

    Mo

  • DTW–ECP, 09/22/26 – 09/29/26: From $319
    22

    Tu

  • DTW–ECP: cmp-view-offers-disclaimer. Find Offers
    23

    We

  • DTW–ECP: cmp-view-offers-disclaimer. Find Offers
    24

    Th

  • DTW–ECP: cmp-view-offers-disclaimer. Find Offers
    25

    Fr

  • DTW–ECP, 09/26/26 – 10/03/26: From $433
    26

    Sa

    • range$319-$793

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Panama City flights

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    Detroit (DTW)to

    Panama City (ECP)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    Detroit (DTW)to

    Panama City (ECP)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $313Fare subject to changes
    Updated: 5 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Panama City

    Looking for lower fares on your trip from Detroit to Panama City? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Detroit to Panama City