American Airlines flights from Des Moines to Columbus

Recent searches for flights from Des Moines to Columbus

Aug 2026
From$506*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$309*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$309*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $309
cmp-daily-histogram-bars-legend-max-price-aria-label $672
Displaying fares for August-2026
  • DSM–CMH, 08/22/26 – 08/29/26: From $535
    22

    Sa

    AUG

  • DSM–CMH, 08/23/26 – 08/30/26: From $672
    23

    Su

  • DSM–CMH, 08/24/26 – 08/31/26: From $672
    24

    Mo

  • DSM–CMH, 08/25/26 – 09/01/26: From $535
    25

    Tu

  • DSM–CMH, 08/26/26 – 09/02/26: From $535
    26

    We

  • DSM–CMH, 08/27/26 – 09/03/26: From $672
    27

    Th

  • DSM–CMH, 08/28/26 – 09/04/26: From $672
    28

    Fr

  • DSM–CMH, 08/29/26 – 09/05/26: From $506
    29

    Sa

  • DSM–CMH, 08/30/26 – 09/06/26: From $612
    30

    Su

  • DSM–CMH, 08/31/26 – 09/07/26: From $612
    31

    Mo

  • DSM–CMH, 09/01/26 – 09/08/26: From $506
    01

    Tu

    SEP

  • DSM–CMH, 09/02/26 – 09/09/26: From $506
    02

    We

  • DSM–CMH, 09/03/26 – 09/10/26: From $612
    03

    Th

  • DSM–CMH, 09/04/26 – 09/11/26: From $612
    04

    Fr

  • DSM–CMH, 09/05/26 – 09/12/26: From $336
    05

    Sa

  • DSM–CMH, 09/06/26 – 09/13/26: From $390
    06

    Su

  • DSM–CMH, 09/07/26 – 09/14/26: From $533
    07

    Mo

  • DSM–CMH, 09/08/26 – 09/15/26: From $393
    08

    Tu

  • DSM–CMH, 09/09/26 – 09/16/26: From $336
    09

    We

  • DSM–CMH, 09/10/26 – 09/17/26: From $336
    10

    Th

  • DSM–CMH, 09/11/26 – 09/18/26: From $349
    11

    Fr

  • DSM–CMH, 09/12/26 – 09/19/26: From $309
    12

    Sa

  • DSM–CMH, 09/13/26 – 09/20/26: From $417
    13

    Su

  • DSM–CMH, 09/14/26 – 09/21/26: From $567
    14

    Mo

  • DSM–CMH, 09/15/26 – 09/22/26: From $309
    15

    Tu

  • DSM–CMH, 09/16/26 – 09/23/26: From $378
    16

    We

  • DSM–CMH, 09/17/26 – 09/24/26: From $551
    17

    Th

  • DSM–CMH, 09/18/26 – 09/25/26: From $335
    18

    Fr

  • DSM–CMH: cmp-view-offers-disclaimer. Find Offers
    19

    Sa

  • DSM–CMH: cmp-view-offers-disclaimer. Find Offers
    20

    Su

  • DSM–CMH, 09/21/26 – 09/28/26: From $309
    21

    Mo

    • range$309-$672

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Columbus flights

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    Des Moines (DSM)to

    Columbus (CMH)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    10/29/26 - 11/05/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    09/21/26 - 09/28/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 17 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    09/29/26 - 10/06/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Columbus (CMH)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Columbus

    Looking for lower fares on your trip from Des Moines to Columbus? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Columbus