American Airlines flights from Des Moines to Grand Cayman

Recent searches for flights from Des Moines to Grand Cayman

Aug 2026
From$851*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$681*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$681*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $681
cmp-daily-histogram-bars-legend-max-price-aria-label $1.2K
Displaying fares for August-2026
  • DSM–GCM, 08/06/26 – 08/13/26: From $1,049
    06

    Th

    AUG

  • DSM–GCM, 08/07/26 – 08/14/26: From $1,244
    07

    Fr

  • DSM–GCM, 08/08/26 – 08/15/26: From $1,047
    08

    Sa

  • DSM–GCM, 08/09/26 – 08/16/26: From $1,054
    09

    Su

  • DSM–GCM, 08/10/26 – 08/17/26: From $1,049
    10

    Mo

  • DSM–GCM, 08/11/26 – 08/18/26: From $1,006
    11

    Tu

  • DSM–GCM, 08/12/26 – 08/19/26: From $1,054
    12

    We

  • DSM–GCM, 08/13/26 – 08/20/26: From $1,049
    13

    Th

  • DSM–GCM, 08/14/26 – 08/21/26: From $1,092
    14

    Fr

  • DSM–GCM, 08/15/26 – 08/22/26: From $1,047
    15

    Sa

  • DSM–GCM, 08/16/26 – 08/23/26: From $1,049
    16

    Su

  • DSM–GCM, 08/17/26 – 08/24/26: From $1,049
    17

    Mo

  • DSM–GCM, 08/18/26 – 08/25/26: From $1,006
    18

    Tu

  • DSM–GCM, 08/19/26 – 08/26/26: From $1,054
    19

    We

  • DSM–GCM, 08/20/26 – 08/27/26: From $1,049
    20

    Th

  • DSM–GCM, 08/21/26 – 08/28/26: From $1,092
    21

    Fr

  • DSM–GCM, 08/22/26 – 08/29/26: From $1,047
    22

    Sa

  • DSM–GCM, 08/23/26 – 08/30/26: From $1,049
    23

    Su

  • DSM–GCM, 08/24/26 – 08/31/26: From $1,049
    24

    Mo

  • DSM–GCM, 08/25/26 – 09/01/26: From $1,006
    25

    Tu

  • DSM–GCM, 08/26/26 – 09/02/26: From $1,054
    26

    We

  • DSM–GCM, 08/27/26 – 09/03/26: From $889
    27

    Th

  • DSM–GCM, 08/28/26 – 09/04/26: From $889
    28

    Fr

  • DSM–GCM, 08/29/26 – 09/05/26: From $884
    29

    Sa

  • DSM–GCM, 08/30/26 – 09/06/26: From $851
    30

    Su

  • DSM–GCM, 08/31/26 – 09/07/26: From $1,194
    31

    Mo

  • DSM–GCM, 09/01/26 – 09/08/26: From $846
    01

    Tu

    SEP

  • DSM–GCM, 09/02/26 – 09/09/26: From $894
    02

    We

  • DSM–GCM, 09/03/26 – 09/10/26: From $686
    03

    Th

  • DSM–GCM, 09/04/26 – 09/11/26: From $686
    04

    Fr

  • DSM–GCM, 09/05/26 – 09/12/26: From $681
    05

    Sa

    • range$681-$1,244

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Grand Cayman flights

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    Des Moines (DSM)to

    Grand Cayman (GCM)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    11/16/26 - 11/23/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Grand Cayman (GCM)
    11/05/26 - 11/12/26

    Round trip

    Economy

    from
    $681Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Grand Cayman

    Looking for lower fares on your trip from Des Moines to Grand Cayman? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Grand Cayman