American Airlines flights from Des Moines to Portland, ME

Recent searches for flights from Des Moines to Portland, ME

Aug 2026
From$297*
Updated: 4 hours ago
Round tripIEconomy
Sep 2026
From$255*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$255*
Updated: 4 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $255
cmp-daily-histogram-bars-legend-max-price-aria-label $727
Displaying fares for August-2026
  • DSM–PWM: cmp-view-offers-disclaimer. Find Offers
    13

    Th

    AUG

  • DSM–PWM, 08/14/26 – 08/21/26: From $681
    14

    Fr

  • DSM–PWM, 08/15/26 – 08/22/26: From $589
    15

    Sa

  • DSM–PWM, 08/16/26 – 08/23/26: From $727
    16

    Su

  • DSM–PWM, 08/17/26 – 08/24/26: From $681
    17

    Mo

  • DSM–PWM, 08/18/26 – 08/25/26: From $589
    18

    Tu

  • DSM–PWM, 08/19/26 – 08/26/26: From $589
    19

    We

  • DSM–PWM, 08/20/26 – 08/27/26: From $644
    20

    Th

  • DSM–PWM, 08/21/26 – 08/28/26: From $644
    21

    Fr

  • DSM–PWM, 08/22/26 – 08/29/26: From $464
    22

    Sa

  • DSM–PWM, 08/23/26 – 08/30/26: From $644
    23

    Su

  • DSM–PWM, 08/24/26 – 08/31/26: From $550
    24

    Mo

  • DSM–PWM, 08/25/26 – 09/01/26: From $459
    25

    Tu

  • DSM–PWM, 08/26/26 – 09/02/26: From $459
    26

    We

  • DSM–PWM, 08/27/26 – 09/03/26: From $386
    27

    Th

  • DSM–PWM, 08/28/26 – 09/04/26: From $420
    28

    Fr

  • DSM–PWM, 08/29/26 – 09/05/26: From $297
    29

    Sa

  • DSM–PWM, 08/30/26 – 09/06/26: From $433
    30

    Su

  • DSM–PWM, 08/31/26 – 09/07/26: From $596
    31

    Mo

  • DSM–PWM, 09/01/26 – 09/08/26: From $444
    01

    Tu

    SEP

  • DSM–PWM, 09/02/26 – 09/09/26: From $292
    02

    We

  • DSM–PWM, 09/03/26 – 09/10/26: From $542
    03

    Th

  • DSM–PWM, 09/04/26 – 09/11/26: From $473
    04

    Fr

  • DSM–PWM, 09/05/26 – 09/12/26: From $255
    05

    Sa

  • DSM–PWM, 09/06/26 – 09/13/26: From $480
    06

    Su

  • DSM–PWM, 09/07/26 – 09/14/26: From $307
    07

    Mo

  • DSM–PWM, 09/08/26 – 09/15/26: From $255
    08

    Tu

  • DSM–PWM, 09/09/26 – 09/16/26: From $255
    09

    We

  • DSM–PWM: cmp-view-offers-disclaimer. Find Offers
    10

    Th

  • DSM–PWM: cmp-view-offers-disclaimer. Find Offers
    11

    Fr

  • DSM–PWM: cmp-view-offers-disclaimer. Find Offers
    12

    Sa

    • range$255-$727

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Portland, ME flights

    $
    keyboard_arrow_down

    Des Moines (DSM)to

    Portland, ME (PWM)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    09/16/26 - 09/23/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    Des Moines (DSM)to

    Portland, ME (PWM)
    09/19/26 - 09/26/26

    Round trip

    Economy

    from
    $255Fare subject to changes
    Updated: 4 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Portland, ME

    Looking for lower fares on your trip from Des Moines to Portland, ME? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Portland, ME