American Airlines flights from Des Moines to San Antonio

Recent searches for flights from Des Moines to San Antonio

Aug 2026
From$338*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$338*
Updated: 2 hours ago
Round tripIEconomy
Oct 2026
From$351*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $338
cmp-daily-histogram-bars-legend-max-price-aria-label $1.0K
Displaying fares for August-2026
  • DSM–SAT, 08/07/26 – 08/14/26: From $892
    07

    Fr

    AUG

  • DSM–SAT, 08/08/26 – 08/15/26: From $1,010
    08

    Sa

  • DSM–SAT, 08/09/26 – 08/16/26: From $1,043
    09

    Su

  • DSM–SAT, 08/10/26 – 08/17/26: From $892
    10

    Mo

  • DSM–SAT, 08/11/26 – 08/18/26: From $865
    11

    Tu

  • DSM–SAT, 08/12/26 – 08/19/26: From $892
    12

    We

  • DSM–SAT, 08/13/26 – 08/20/26: From $892
    13

    Th

  • DSM–SAT, 08/14/26 – 08/21/26: From $673
    14

    Fr

  • DSM–SAT, 08/15/26 – 08/22/26: From $673
    15

    Sa

  • DSM–SAT, 08/16/26 – 08/23/26: From $673
    16

    Su

  • DSM–SAT, 08/17/26 – 08/24/26: From $673
    17

    Mo

  • DSM–SAT, 08/18/26 – 08/25/26: From $673
    18

    Tu

  • DSM–SAT, 08/19/26 – 08/26/26: From $673
    19

    We

  • DSM–SAT, 08/20/26 – 08/27/26: From $673
    20

    Th

  • DSM–SAT, 08/21/26 – 08/28/26: From $441
    21

    Fr

  • DSM–SAT, 08/22/26 – 08/29/26: From $424
    22

    Sa

  • DSM–SAT, 08/23/26 – 08/30/26: From $467
    23

    Su

  • DSM–SAT, 08/24/26 – 08/31/26: From $424
    24

    Mo

  • DSM–SAT, 08/25/26 – 09/01/26: From $424
    25

    Tu

  • DSM–SAT, 08/26/26 – 09/02/26: From $424
    26

    We

  • DSM–SAT, 08/27/26 – 08/30/26: From $394
    27

    Th

  • DSM–SAT, 08/28/26 – 09/04/26: From $385
    28

    Fr

  • DSM–SAT, 08/29/26 – 09/05/26: From $338
    29

    Sa

  • DSM–SAT, 08/30/26 – 09/06/26: From $381
    30

    Su

  • DSM–SAT, 08/31/26 – 09/07/26: From $351
    31

    Mo

  • DSM–SAT, 09/01/26 – 09/08/26: From $351
    01

    Tu

    SEP

  • DSM–SAT, 09/02/26 – 09/09/26: From $351
    02

    We

  • DSM–SAT, 09/03/26 – 09/06/26: From $338
    03

    Th

  • DSM–SAT: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

  • DSM–SAT: cmp-view-offers-disclaimer. Find Offers
    05

    Sa

  • DSM–SAT, 09/06/26 – 09/13/26: From $371
    06

    Su

    • range$338-$1,043

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to San Antonio flights

    $
    keyboard_arrow_down

    Des Moines (DSM)to

    San Antonio (SAT)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $338Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    09/03/26 - 09/06/26

    Round trip

    Economy

    from
    $338Fare subject to changes
    Updated: 2 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    09/02/26 - 09/09/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    San Antonio (SAT)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $351Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to San Antonio

    Looking for lower fares on your trip from Des Moines to San Antonio? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to San Antonio