American Airlines flights from Detroit to Greenville

Recent searches for flights from Detroit to Greenville

Jul 2026
From$639*
Updated: 12 hours ago
Round tripIEconomy
Aug 2026
From$321*
Updated: 2 hours ago
Round tripIEconomy
Sep 2026
From$321*
Updated: 2 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $321
cmp-daily-histogram-bars-legend-max-price-aria-label $659
Displaying fares for July-2026
  • DTW–GSP, 07/31/26 – 08/07/26: From $639
    31

    Fr

    JUL

  • DTW–GSP, 08/01/26 – 08/08/26: From $387
    01

    Sa

  • DTW–GSP, 08/02/26 – 08/09/26: From $659
    02

    Su

  • DTW–GSP, 08/03/26 – 08/10/26: From $659
    03

    Mo

  • DTW–GSP, 08/04/26 – 08/11/26: From $387
    04

    Tu

  • DTW–GSP, 08/05/26 – 08/12/26: From $387
    05

    We

  • DTW–GSP, 08/06/26 – 08/13/26: From $619
    06

    Th

  • DTW–GSP, 08/07/26 – 08/14/26: From $619
    07

    Fr

  • DTW–GSP, 08/08/26 – 08/15/26: From $387
    08

    Sa

  • DTW–GSP, 08/09/26 – 08/16/26: From $619
    09

    Su

  • DTW–GSP, 08/10/26 – 08/17/26: From $619
    10

    Mo

  • DTW–GSP, 08/11/26 – 08/18/26: From $387
    11

    Tu

  • DTW–GSP, 08/12/26 – 08/19/26: From $387
    12

    We

  • DTW–GSP, 08/13/26 – 08/20/26: From $430
    13

    Th

  • DTW–GSP, 08/14/26 – 08/21/26: From $509
    14

    Fr

  • DTW–GSP, 08/15/26 – 08/22/26: From $387
    15

    Sa

  • DTW–GSP, 08/16/26 – 08/23/26: From $509
    16

    Su

  • DTW–GSP, 08/17/26 – 08/24/26: From $509
    17

    Mo

  • DTW–GSP, 08/18/26 – 08/25/26: From $354
    18

    Tu

  • DTW–GSP, 08/19/26 – 08/26/26: From $354
    19

    We

  • DTW–GSP, 08/20/26 – 08/27/26: From $400
    20

    Th

  • DTW–GSP, 08/21/26 – 08/28/26: From $479
    21

    Fr

  • DTW–GSP, 08/22/26 – 08/29/26: From $354
    22

    Sa

  • DTW–GSP, 08/23/26 – 08/30/26: From $459
    23

    Su

  • DTW–GSP, 08/24/26 – 08/31/26: From $400
    24

    Mo

  • DTW–GSP, 08/25/26 – 09/01/26: From $321
    25

    Tu

  • DTW–GSP, 08/26/26 – 09/02/26: From $354
    26

    We

  • DTW–GSP, 08/27/26 – 09/03/26: From $459
    27

    Th

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    28

    Fr

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    29

    Sa

  • DTW–GSP, 08/30/26 – 09/06/26: From $419
    30

    Su

    • range$321-$659

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Greenville flights

    $
    keyboard_arrow_down

    Detroit (DTW)to

    Greenville (GSP)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    09/01/26 - 09/08/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    09/24/26 - 10/01/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 2 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Greenville

    Looking for lower fares on your trip from Detroit to Greenville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Detroit to Greenville