American Airlines flights from Detroit to Greenville

Recent searches for flights from Detroit to Greenville

Sep 2026
From$464*
Updated: 13 hours ago
Round tripIEconomy
Oct 2026
From$321*
Updated: 13 hours ago
Round tripIEconomy
Nov 2026
From$321*
Updated: 13 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $321
cmp-daily-histogram-bars-legend-max-price-aria-label $886
Displaying fares for September-2026
  • DTW–GSP, 09/09/26 – 09/16/26: From $559
    09

    We

    SEP

  • DTW–GSP, 09/10/26 – 09/17/26: From $559
    10

    Th

  • DTW–GSP, 09/11/26 – 09/18/26: From $559
    11

    Fr

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    12

    Sa

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    13

    Su

  • DTW–GSP, 09/14/26 – 09/21/26: From $863
    14

    Mo

  • DTW–GSP, 09/15/26 – 09/22/26: From $559
    15

    Tu

  • DTW–GSP, 09/16/26 – 09/23/26: From $559
    16

    We

  • DTW–GSP, 09/17/26 – 09/24/26: From $559
    17

    Th

  • DTW–GSP, 09/18/26 – 09/25/26: From $763
    18

    Fr

  • DTW–GSP, 09/19/26 – 09/26/26: From $850
    19

    Sa

  • DTW–GSP, 09/20/26 – 09/27/26: From $886
    20

    Su

  • DTW–GSP, 09/21/26 – 09/28/26: From $559
    21

    Mo

  • DTW–GSP, 09/22/26 – 09/29/26: From $559
    22

    Tu

  • DTW–GSP, 09/23/26 – 09/30/26: From $558
    23

    We

  • DTW–GSP, 09/24/26 – 10/01/26: From $559
    24

    Th

  • DTW–GSP, 09/25/26 – 10/02/26: From $559
    25

    Fr

  • DTW–GSP, 09/26/26 – 10/03/26: From $464
    26

    Sa

  • DTW–GSP, 09/27/26 – 10/04/26: From $559
    27

    Su

  • DTW–GSP, 09/28/26 – 10/05/26: From $559
    28

    Mo

  • DTW–GSP, 09/29/26 – 10/06/26: From $505
    29

    Tu

  • DTW–GSP, 09/30/26 – 10/07/26: From $489
    30

    We

  • DTW–GSP, 10/01/26 – 10/08/26: From $489
    01

    Th

    OCT

  • DTW–GSP, 10/02/26 – 10/09/26: From $498
    02

    Fr

  • DTW–GSP, 10/03/26 – 10/10/26: From $387
    03

    Sa

  • DTW–GSP, 10/04/26 – 10/11/26: From $486
    04

    Su

  • DTW–GSP, 10/05/26 – 10/12/26: From $486
    05

    Mo

  • DTW–GSP, 10/06/26 – 10/13/26: From $321
    06

    Tu

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    07

    We

  • DTW–GSP: cmp-view-offers-disclaimer. Find Offers
    08

    Th

    • range$321-$886

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Greenville flights

    $
    keyboard_arrow_down

    Detroit (DTW)to

    Greenville (GSP)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    12/03/26 - 12/10/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    Detroit (DTW)to

    Greenville (GSP)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $321Fare subject to changes
    Updated: 13 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Greenville

    Looking for lower fares on your trip from Detroit to Greenville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Detroit to Greenville