American Airlines flights from United States to Cayman Islands

Popular flights with American Airlines

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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights from United States to the Cayman Islands

Business class flights from United States to Cayman Islands

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Dallas (DFW)to

Grand Cayman (GCM)
12/04/25 - 12/09/25

Round trip

Business / First

from
$2,091Fare subject to changes
Updated: 4 hours ago

Charlotte (CLT)to

Grand Cayman (GCM)
12/15/25 - 12/19/25

Round trip

Business / First

from
$1,701Fare subject to changes
Updated: 8 hours ago

Chicago (ORD)to

Grand Cayman (GCM)
12/06/25 - 12/12/25

Round trip

Business / First

from
$2,371Fare subject to changes
Updated: 7 hours ago

Kansas City (MCI)to

Grand Cayman (GCM)
12/26/25 - 01/03/26

Round trip

Business / First

from
$7,191Fare subject to changes
Updated: 7 hours ago

Buffalo (BUF)to

Grand Cayman (GCM)
02/12/26 - 02/17/26

Round trip

Business / First

from
$1,395Fare subject to changes
Updated: 7 hours ago

Seattle (SEA)to

Grand Cayman (GCM)
02/11/26 - 02/18/26

Round trip

Business / First

from
$1,496Fare subject to changes
Updated: 2 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Find deals on United States to Cayman Islands flights

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Dallas (DFW)to

Grand Cayman (GCM)
12/16/25 - 12/23/25

Round trip

Economy

from
$502Fare subject to changes
Updated: 2 hours ago

Miami (MIA)to

Grand Cayman (GCM)
12/10/25 - 12/17/25

Round trip

Economy

from
$296Fare subject to changes
Updated: 3 hours ago

Charlotte (CLT)to

Grand Cayman (GCM)
02/10/26 - 02/17/26

Round trip

Economy

from
$326Fare subject to changes
Updated: 5 hours ago

Chicago (ORD)to

Grand Cayman (GCM)
02/04/26 - 02/11/26

Round trip

Economy

from
$330Fare subject to changes
Updated: 2 hours ago

Philadelphia (PHL)to

Grand Cayman (GCM)
11/18/25 - 11/25/25

Round trip

Economy

from
$520Fare subject to changes
Updated: 3 hours ago

New York (NYC)to

Grand Cayman (GCM)
12/09/25 - 12/16/25

Round trip

Economy

from
$304Fare subject to changes
Updated: 2 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

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Top United States to Cayman Islands routes