American Airlines flights from Des Moines to Myrtle Beach

Recent searches for flights from Des Moines to Myrtle Beach

Aug 2026
From$807*
Updated: 3 hours ago
Round tripIEconomy
Sep 2026
From$371*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$297*
Updated: 23 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $371
cmp-daily-histogram-bars-legend-max-price-aria-label $966
Displaying fares for August-2026
  • DSM–MYR, 08/28/26 – 09/04/26: From $892
    28

    Fr

    AUG

  • DSM–MYR, 08/29/26 – 09/05/26: From $807
    29

    Sa

  • DSM–MYR, 08/30/26 – 09/06/26: From $892
    30

    Su

  • DSM–MYR, 08/31/26 – 09/07/26: From $892
    31

    Mo

  • DSM–MYR, 09/01/26 – 09/08/26: From $892
    01

    Tu

    SEP

  • DSM–MYR, 09/02/26 – 09/09/26: From $870
    02

    We

  • DSM–MYR, 09/03/26 – 09/10/26: From $966
    03

    Th

  • DSM–MYR, 09/04/26 – 09/11/26: From $673
    04

    Fr

  • DSM–MYR, 09/05/26 – 09/12/26: From $411
    05

    Sa

  • DSM–MYR, 09/06/26 – 09/13/26: From $411
    06

    Su

  • DSM–MYR, 09/07/26 – 09/14/26: From $673
    07

    Mo

  • DSM–MYR, 09/08/26 – 09/15/26: From $673
    08

    Tu

  • DSM–MYR, 09/09/26 – 09/16/26: From $673
    09

    We

  • DSM–MYR, 09/10/26 – 09/17/26: From $411
    10

    Th

  • DSM–MYR, 09/11/26 – 09/18/26: From $381
    11

    Fr

  • DSM–MYR, 09/12/26 – 09/19/26: From $381
    12

    Sa

  • DSM–MYR, 09/13/26 – 09/20/26: From $609
    13

    Su

  • DSM–MYR, 09/14/26 – 09/21/26: From $434
    14

    Mo

  • DSM–MYR, 09/15/26 – 09/22/26: From $434
    15

    Tu

  • DSM–MYR, 09/16/26 – 09/23/26: From $434
    16

    We

  • DSM–MYR, 09/17/26 – 09/24/26: From $555
    17

    Th

  • DSM–MYR, 09/18/26 – 09/25/26: From $371
    18

    Fr

  • DSM–MYR, 09/19/26 – 09/26/26: From $404
    19

    Sa

  • DSM–MYR, 09/20/26 – 09/27/26: From $467
    20

    Su

  • DSM–MYR, 09/21/26 – 09/28/26: From $371
    21

    Mo

  • DSM–MYR, 09/22/26 – 09/29/26: From $371
    22

    Tu

  • DSM–MYR, 09/23/26 – 09/30/26: From $371
    23

    We

  • DSM–MYR, 09/24/26 – 10/01/26: From $409
    24

    Th

  • DSM–MYR: cmp-view-offers-disclaimer. Find Offers
    25

    Fr

  • DSM–MYR: cmp-view-offers-disclaimer. Find Offers
    26

    Sa

  • DSM–MYR, 09/27/26 – 10/04/26: From $609
    27

    Su

    • range$371-$966

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Myrtle Beach flights

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    Des Moines (DSM)to

    Myrtle Beach (MYR)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $297Fare subject to changes
    Updated: 23 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    09/21/26 - 09/28/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    Myrtle Beach (MYR)
    09/28/26 - 10/05/26

    Round trip

    Economy

    from
    $371Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Myrtle Beach

    Looking for lower fares on your trip from Des Moines to Myrtle Beach? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Myrtle Beach