American Airlines flights from Des Moines to San Francisco

Recent searches for flights from Des Moines to San Francisco

Aug 2026
From$449*
Updated: 3 hours ago
Round tripIEconomy
Sep 2026
From$303*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$303*
Updated: 5 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $303
cmp-daily-histogram-bars-legend-max-price-aria-label $1.0K
Displaying fares for August-2026
  • DSM–SFO, 08/13/26 – 08/20/26: From $1,022
    13

    Th

    AUG

  • DSM–SFO, 08/14/26 – 08/21/26: From $961
    14

    Fr

  • DSM–SFO, 08/15/26 – 08/22/26: From $795
    15

    Sa

  • DSM–SFO, 08/16/26 – 08/23/26: From $1,022
    16

    Su

  • DSM–SFO, 08/17/26 – 08/24/26: From $961
    17

    Mo

  • DSM–SFO, 08/18/26 – 08/25/26: From $795
    18

    Tu

  • DSM–SFO, 08/19/26 – 08/26/26: From $795
    19

    We

  • DSM–SFO, 08/20/26 – 08/27/26: From $779
    20

    Th

  • DSM–SFO, 08/21/26 – 08/28/26: From $779
    21

    Fr

  • DSM–SFO, 08/22/26 – 08/29/26: From $677
    22

    Sa

  • DSM–SFO, 08/23/26 – 08/30/26: From $779
    23

    Su

  • DSM–SFO, 08/24/26 – 08/31/26: From $669
    24

    Mo

  • DSM–SFO, 08/25/26 – 09/01/26: From $567
    25

    Tu

  • DSM–SFO, 08/26/26 – 09/02/26: From $519
    26

    We

  • DSM–SFO, 08/27/26 – 09/03/26: From $452
    27

    Th

  • DSM–SFO, 08/28/26 – 09/04/26: From $494
    28

    Fr

  • DSM–SFO, 08/29/26 – 09/05/26: From $449
    29

    Sa

  • DSM–SFO, 08/30/26 – 09/06/26: From $449
    30

    Su

  • DSM–SFO, 08/31/26 – 09/07/26: From $508
    31

    Mo

  • DSM–SFO, 09/01/26 – 09/08/26: From $342
    01

    Tu

    SEP

  • DSM–SFO, 09/02/26 – 09/09/26: From $342
    02

    We

  • DSM–SFO, 09/03/26 – 09/10/26: From $307
    03

    Th

  • DSM–SFO, 09/04/26 – 09/11/26: From $346
    04

    Fr

  • DSM–SFO, 09/05/26 – 09/12/26: From $303
    05

    Sa

  • DSM–SFO, 09/06/26 – 09/13/26: From $389
    06

    Su

  • DSM–SFO, 09/07/26 – 09/14/26: From $306
    07

    Mo

  • DSM–SFO, 09/08/26 – 09/15/26: From $372
    08

    Tu

  • DSM–SFO, 09/09/26 – 09/16/26: From $306
    09

    We

  • DSM–SFO: cmp-view-offers-disclaimer. Find Offers
    10

    Th

  • DSM–SFO: cmp-view-offers-disclaimer. Find Offers
    11

    Fr

  • DSM–SFO, 09/12/26 – 09/19/26: From $305
    12

    Sa

    • range$303-$1,022

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to San Francisco flights

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    Des Moines (DSM)to

    San Francisco (SFO)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 21 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $303Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    10/02/26 - 10/05/26

    Round trip

    Economy

    from
    $303Fare subject to changes
    Updated: 5 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    09/16/26 - 09/23/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 3 hours ago

    Des Moines (DSM)to

    San Francisco (SFO)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $305Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to San Francisco

    Looking for lower fares on your trip from Des Moines to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to San Francisco