American Airlines flights from Detroit to Saint Louis

Recent searches for flights from Detroit to Saint Louis

Aug 2026
From$262*
Updated: 10 hours ago
Round tripIEconomy
Sep 2026
From$262*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$262*
Updated: 10 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $262
cmp-daily-histogram-bars-legend-max-price-aria-label $776
Displaying fares for August-2026
  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    08

    Sa

    AUG

  • DTW–STL, 08/09/26 – 08/16/26: From $776
    09

    Su

  • DTW–STL, 08/10/26 – 08/17/26: From $776
    10

    Mo

  • DTW–STL, 08/11/26 – 08/18/26: From $776
    11

    Tu

  • DTW–STL, 08/12/26 – 08/19/26: From $776
    12

    We

  • DTW–STL, 08/13/26 – 08/20/26: From $776
    13

    Th

  • DTW–STL, 08/14/26 – 08/21/26: From $776
    14

    Fr

  • DTW–STL, 08/15/26 – 08/22/26: From $622
    15

    Sa

  • DTW–STL, 08/16/26 – 08/23/26: From $650
    16

    Su

  • DTW–STL, 08/17/26 – 08/24/26: From $650
    17

    Mo

  • DTW–STL, 08/18/26 – 08/25/26: From $622
    18

    Tu

  • DTW–STL, 08/19/26 – 08/26/26: From $622
    19

    We

  • DTW–STL, 08/20/26 – 08/27/26: From $622
    20

    Th

  • DTW–STL, 08/21/26 – 08/28/26: From $622
    21

    Fr

  • DTW–STL, 08/22/26 – 08/29/26: From $381
    22

    Sa

  • DTW–STL, 08/23/26 – 08/30/26: From $401
    23

    Su

  • DTW–STL, 08/24/26 – 08/31/26: From $381
    24

    Mo

  • DTW–STL, 08/25/26 – 09/01/26: From $381
    25

    Tu

  • DTW–STL, 08/26/26 – 09/02/26: From $381
    26

    We

  • DTW–STL, 08/27/26 – 09/03/26: From $381
    27

    Th

  • DTW–STL, 08/28/26 – 09/04/26: From $503
    28

    Fr

  • DTW–STL, 08/29/26 – 09/05/26: From $262
    29

    Sa

  • DTW–STL, 08/30/26 – 09/06/26: From $282
    30

    Su

  • DTW–STL, 08/31/26 – 09/07/26: From $409
    31

    Mo

  • DTW–STL, 09/01/26 – 09/08/26: From $287
    01

    Tu

    SEP

  • DTW–STL, 09/02/26 – 09/09/26: From $287
    02

    We

  • DTW–STL, 09/03/26 – 09/10/26: From $287
    03

    Th

  • DTW–STL, 09/04/26 – 09/11/26: From $262
    04

    Fr

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    05

    Sa

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    06

    Su

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    07

    Mo

    • range$262-$776

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Saint Louis flights

    $
    keyboard_arrow_down

    Detroit (DTW)to

    Saint Louis (STL)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $262Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    09/04/26 - 09/11/26

    Round trip

    Economy

    from
    $262Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    09/11/26 - 09/18/26

    Round trip

    Economy

    from
    $262Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $262Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    08/30/26 - 09/06/26

    Round trip

    Economy

    from
    $282Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Detroit (DTW)to

    Saint Louis (STL)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Saint Louis

    Looking for lower fares on your trip from Detroit to Saint Louis? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Detroit to Saint Louis