American Airlines flights from Knoxville to San Francisco

Recent searches for flights from Knoxville to San Francisco

Aug 2026
From$557*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$363*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$363*
Updated: 10 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $363
cmp-daily-histogram-bars-legend-max-price-aria-label $735
Displaying fares for August-2026
  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    24

    Mo

    AUG

  • TYS–SFO, 08/25/26 – 09/01/26: From $559
    25

    Tu

  • TYS–SFO, 08/26/26 – 09/02/26: From $557
    26

    We

  • TYS–SFO, 08/27/26 – 09/03/26: From $735
    27

    Th

  • TYS–SFO, 08/28/26 – 09/04/26: From $735
    28

    Fr

  • TYS–SFO, 08/29/26 – 09/05/26: From $559
    29

    Sa

  • TYS–SFO, 08/30/26 – 09/06/26: From $735
    30

    Su

  • TYS–SFO, 08/31/26 – 09/07/26: From $697
    31

    Mo

  • TYS–SFO, 09/01/26 – 09/08/26: From $559
    01

    Tu

    SEP

  • TYS–SFO, 09/02/26 – 09/09/26: From $461
    02

    We

  • TYS–SFO, 09/03/26 – 09/10/26: From $648
    03

    Th

  • TYS–SFO, 09/04/26 – 09/11/26: From $648
    04

    Fr

  • TYS–SFO, 09/05/26 – 09/12/26: From $378
    05

    Sa

  • TYS–SFO, 09/06/26 – 09/13/26: From $477
    06

    Su

  • TYS–SFO, 09/07/26 – 09/14/26: From $698
    07

    Mo

  • TYS–SFO, 09/08/26 – 09/15/26: From $511
    08

    Tu

  • TYS–SFO, 09/09/26 – 09/16/26: From $363
    09

    We

  • TYS–SFO, 09/10/26 – 09/17/26: From $713
    10

    Th

  • TYS–SFO, 09/11/26 – 09/18/26: From $564
    11

    Fr

  • TYS–SFO, 09/12/26 – 09/19/26: From $363
    12

    Sa

  • TYS–SFO, 09/13/26 – 09/20/26: From $593
    13

    Su

  • TYS–SFO, 09/14/26 – 09/21/26: From $511
    14

    Mo

  • TYS–SFO, 09/15/26 – 09/22/26: From $363
    15

    Tu

  • TYS–SFO, 09/16/26 – 09/23/26: From $363
    16

    We

  • TYS–SFO, 09/17/26 – 09/24/26: From $593
    17

    Th

  • TYS–SFO, 09/18/26 – 09/25/26: From $496
    18

    Fr

  • TYS–SFO, 09/19/26 – 09/26/26: From $363
    19

    Sa

  • TYS–SFO, 09/20/26 – 09/27/26: From $645
    20

    Su

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    21

    Mo

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    22

    Tu

  • TYS–SFO, 09/23/26 – 09/28/26: From $363
    23

    We

    • range$363-$735

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to San Francisco flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    San Francisco (SFO)
    11/05/26 - 11/12/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    11/09/26 - 11/16/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    11/19/26 - 11/26/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $363Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to San Francisco

    Looking for lower fares on your trip from Knoxville to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to San Francisco