American Airlines flights from Knoxville to San Francisco

Recent searches for flights from Knoxville to San Francisco

Aug 2026
From$376*
Updated: 3 hours ago
Round tripIEconomy
Sep 2026
From$376*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$389*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $376
cmp-daily-histogram-bars-legend-max-price-aria-label $735
Displaying fares for August-2026
  • TYS–SFO, 08/04/26 – 08/11/26: From $559
    04

    Tu

    AUG

  • TYS–SFO, 08/05/26 – 08/12/26: From $559
    05

    We

  • TYS–SFO, 08/06/26 – 08/13/26: From $735
    06

    Th

  • TYS–SFO, 08/07/26 – 08/14/26: From $735
    07

    Fr

  • TYS–SFO, 08/08/26 – 08/15/26: From $559
    08

    Sa

  • TYS–SFO, 08/09/26 – 08/16/26: From $735
    09

    Su

  • TYS–SFO, 08/10/26 – 08/17/26: From $735
    10

    Mo

  • TYS–SFO, 08/11/26 – 08/18/26: From $485
    11

    Tu

  • TYS–SFO, 08/12/26 – 08/19/26: From $485
    12

    We

  • TYS–SFO, 08/13/26 – 08/20/26: From $648
    13

    Th

  • TYS–SFO, 08/14/26 – 08/21/26: From $648
    14

    Fr

  • TYS–SFO, 08/15/26 – 08/22/26: From $485
    15

    Sa

  • TYS–SFO, 08/16/26 – 08/23/26: From $648
    16

    Su

  • TYS–SFO, 08/17/26 – 08/24/26: From $648
    17

    Mo

  • TYS–SFO, 08/18/26 – 08/25/26: From $400
    18

    Tu

  • TYS–SFO, 08/19/26 – 08/26/26: From $400
    19

    We

  • TYS–SFO, 08/20/26 – 08/27/26: From $475
    20

    Th

  • TYS–SFO, 08/21/26 – 08/28/26: From $495
    21

    Fr

  • TYS–SFO, 08/22/26 – 08/29/26: From $400
    22

    Sa

  • TYS–SFO, 08/23/26 – 08/30/26: From $544
    23

    Su

  • TYS–SFO, 08/24/26 – 08/31/26: From $475
    24

    Mo

  • TYS–SFO, 08/25/26 – 09/01/26: From $389
    25

    Tu

  • TYS–SFO, 08/26/26 – 09/02/26: From $389
    26

    We

  • TYS–SFO, 08/27/26 – 09/03/26: From $496
    27

    Th

  • TYS–SFO, 08/28/26 – 09/04/26: From $516
    28

    Fr

  • TYS–SFO, 08/29/26 – 09/05/26: From $376
    29

    Sa

  • TYS–SFO, 08/30/26 – 09/06/26: From $445
    30

    Su

  • TYS–SFO, 08/31/26 – 09/07/26: From $450
    31

    Mo

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    01

    Tu

    SEP

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    02

    We

  • TYS–SFO, 09/03/26 – 09/10/26: From $389
    03

    Th

    • range$376-$735

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to San Francisco flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    San Francisco (SFO)
    09/03/26 - 09/10/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 19 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $376Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $376Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/26/26 - 11/02/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    08/25/26 - 09/01/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Francisco (SFO)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $389Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to San Francisco

    Looking for lower fares on your trip from Knoxville to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to San Francisco