American Airlines flights from Manchester to Knoxville

Recent searches for flights from Manchester to Knoxville

Sep 2026
From$359*
Updated: 19 minutes ago
Round tripIEconomy
Oct 2026
From$359*
Updated: 19 minutes ago
Round tripIEconomy
Nov 2026
From$359*
Updated: 19 minutes ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $359
cmp-daily-histogram-bars-legend-max-price-aria-label $840
Displaying fares for September-2026
  • MHT–TYS, 09/05/26 – 09/12/26: From $497
    05

    Sa

    SEP

  • MHT–TYS, 09/06/26 – 09/13/26: From $629
    06

    Su

  • MHT–TYS, 09/07/26 – 09/14/26: From $629
    07

    Mo

  • MHT–TYS, 09/08/26 – 09/15/26: From $587
    08

    Tu

  • MHT–TYS, 09/09/26 – 09/16/26: From $497
    09

    We

  • MHT–TYS, 09/10/26 – 09/17/26: From $629
    10

    Th

  • MHT–TYS, 09/11/26 – 09/18/26: From $629
    11

    Fr

  • MHT–TYS, 09/12/26 – 09/19/26: From $492
    12

    Sa

  • MHT–TYS, 09/13/26 – 09/20/26: From $766
    13

    Su

  • MHT–TYS, 09/14/26 – 09/21/26: From $598
    14

    Mo

  • MHT–TYS, 09/15/26 – 09/22/26: From $492
    15

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  • MHT–TYS, 09/16/26 – 09/23/26: From $492
    16

    We

  • MHT–TYS, 09/17/26 – 09/24/26: From $629
    17

    Th

  • MHT–TYS, 09/18/26 – 09/25/26: From $671
    18

    Fr

  • MHT–TYS, 09/19/26 – 09/26/26: From $423
    19

    Sa

  • MHT–TYS, 09/20/26 – 09/27/26: From $840
    20

    Su

  • MHT–TYS, 09/21/26 – 09/28/26: From $423
    21

    Mo

  • MHT–TYS, 09/22/26 – 09/29/26: From $423
    22

    Tu

  • MHT–TYS, 09/23/26 – 09/30/26: From $423
    23

    We

  • MHT–TYS, 09/24/26 – 10/01/26: From $640
    24

    Th

  • MHT–TYS, 09/25/26 – 10/02/26: From $808
    25

    Fr

  • MHT–TYS, 09/26/26 – 10/03/26: From $523
    26

    Sa

  • MHT–TYS, 09/27/26 – 10/04/26: From $735
    27

    Su

  • MHT–TYS, 09/28/26 – 10/05/26: From $433
    28

    Mo

  • MHT–TYS, 09/29/26 – 10/06/26: From $359
    29

    Tu

  • MHT–TYS, 09/30/26 – 10/07/26: From $359
    30

    We

  • MHT–TYS, 10/01/26 – 10/08/26: From $359
    01

    Th

    OCT

  • MHT–TYS, 10/02/26 – 10/09/26: From $359
    02

    Fr

  • MHT–TYS, 10/03/26 – 10/10/26: From $359
    03

    Sa

  • MHT–TYS: cmp-view-offers-disclaimer. Find Offers
    04

    Su

    • range$359-$840

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Manchester to Knoxville flights

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    keyboard_arrow_down

    Manchester (MHT)to

    Knoxville (TYS)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/30/26 - 11/06/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/01/26 - 10/08/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    Manchester (MHT)to

    Knoxville (TYS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $359Fare subject to changes
    Updated: 19 minutes ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Manchester to Knoxville

    Looking for lower fares on your trip from Manchester to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Manchester to Knoxville