American Airlines flights from Charleston, SC to Knoxville

Recent searches for flights from Charleston, SC to Knoxville

Sep 2026
From$437*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$367*
Updated: 17 hours ago
Round tripIEconomy
Nov 2026
From$367*
Updated: 17 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $387
cmp-daily-histogram-bars-legend-max-price-aria-label $979
Displaying fares for September-2026
  • CHS–TYS, 09/13/26 – 09/20/26: From $643
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    SEP

  • CHS–TYS, 09/14/26 – 09/21/26: From $643
    14

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  • CHS–TYS, 09/15/26 – 09/22/26: From $643
    15

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  • CHS–TYS, 09/16/26 – 09/23/26: From $643
    16

    We

  • CHS–TYS, 09/17/26 – 09/24/26: From $643
    17

    Th

  • CHS–TYS, 09/18/26 – 09/25/26: From $669
    18

    Fr

  • CHS–TYS, 09/19/26 – 09/26/26: From $532
    19

    Sa

  • CHS–TYS, 09/20/26 – 09/27/26: From $979
    20

    Su

  • CHS–TYS, 09/21/26 – 09/28/26: From $532
    21

    Mo

  • CHS–TYS, 09/22/26 – 09/29/26: From $532
    22

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  • CHS–TYS, 09/23/26 – 09/30/26: From $532
    23

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  • CHS–TYS, 09/24/26 – 10/01/26: From $664
    24

    Th

  • CHS–TYS, 09/25/26 – 10/02/26: From $779
    25

    Fr

  • CHS–TYS, 09/26/26 – 10/03/26: From $437
    26

    Sa

  • CHS–TYS, 09/27/26 – 10/04/26: From $798
    27

    Su

  • CHS–TYS, 09/28/26 – 10/05/26: From $437
    28

    Mo

  • CHS–TYS, 09/29/26 – 10/06/26: From $437
    29

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  • CHS–TYS, 09/30/26 – 10/07/26: From $437
    30

    We

  • CHS–TYS, 10/01/26 – 10/08/26: From $517
    01

    Th

    OCT

  • CHS–TYS, 10/02/26 – 10/09/26: From $437
    02

    Fr

  • CHS–TYS, 10/03/26 – 10/10/26: From $407
    03

    Sa

  • CHS–TYS, 10/04/26 – 10/11/26: From $567
    04

    Su

  • CHS–TYS, 10/05/26 – 10/12/26: From $387
    05

    Mo

  • CHS–TYS, 10/06/26 – 10/13/26: From $387
    06

    Tu

  • CHS–TYS, 10/07/26 – 10/14/26: From $387
    07

    We

  • CHS–TYS, 10/08/26 – 10/15/26: From $467
    08

    Th

  • CHS–TYS, 10/09/26 – 10/16/26: From $563
    09

    Fr

  • CHS–TYS, 10/10/26 – 10/17/26: From $563
    10

    Sa

  • CHS–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Su

  • CHS–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

    • range$387-$979

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Charleston, SC to Knoxville flights

    $
    keyboard_arrow_down

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 17 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    12/03/26 - 12/10/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Charleston, SC to Knoxville

    Looking for lower fares on your trip from Charleston, SC to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Charleston, SC to Knoxville