American Airlines flights from Charleston, SC to Knoxville

Recent searches for flights from Charleston, SC to Knoxville

Aug 2026
From$512*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$273*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$273*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $273
cmp-daily-histogram-bars-legend-max-price-aria-label $659
Displaying fares for August-2026
  • CHS–TYS, 08/23/26 – 08/30/26: From $623
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  • CHS–TYS, 08/24/26 – 08/31/26: From $623
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  • CHS–TYS, 08/26/26 – 09/02/26: From $623
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  • CHS–TYS, 08/27/26 – 09/03/26: From $623
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  • CHS–TYS, 08/28/26 – 09/04/26: From $623
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  • CHS–TYS, 08/29/26 – 09/05/26: From $623
    29

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  • CHS–TYS, 08/30/26 – 09/06/26: From $512
    30

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  • CHS–TYS, 08/31/26 – 09/07/26: From $512
    31

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  • CHS–TYS, 09/01/26 – 09/08/26: From $512
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  • CHS–TYS, 09/02/26 – 09/09/26: From $512
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  • CHS–TYS, 09/03/26 – 09/10/26: From $512
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  • CHS–TYS, 09/04/26 – 09/11/26: From $512
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  • CHS–TYS, 09/05/26 – 09/12/26: From $360
    05

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  • CHS–TYS, 09/06/26 – 09/13/26: From $425
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  • CHS–TYS, 09/07/26 – 09/14/26: From $659
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  • CHS–TYS, 09/08/26 – 09/15/26: From $360
    08

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  • CHS–TYS, 09/09/26 – 09/16/26: From $273
    09

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  • CHS–TYS, 09/10/26 – 09/17/26: From $512
    10

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  • CHS–TYS, 09/11/26 – 09/18/26: From $296
    11

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  • CHS–TYS, 09/12/26 – 09/19/26: From $273
    12

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  • CHS–TYS, 09/13/26 – 09/20/26: From $578
    13

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  • CHS–TYS, 09/14/26 – 09/21/26: From $448
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  • CHS–TYS, 09/15/26 – 09/22/26: From $273
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  • CHS–TYS, 09/16/26 – 09/23/26: From $273
    16

    We

  • CHS–TYS, 09/17/26 – 09/24/26: From $577
    17

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  • CHS–TYS, 09/18/26 – 09/25/26: From $434
    18

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  • CHS–TYS, 09/19/26 – 09/26/26: From $296
    19

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  • CHS–TYS: cmp-view-offers-disclaimer. Find Offers
    20

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  • CHS–TYS: cmp-view-offers-disclaimer. Find Offers
    21

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  • CHS–TYS, 09/22/26 – 09/29/26: From $273
    22

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    • range$273-$659

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Charleston, SC to Knoxville flights

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    Charleston, SC (CHS)to

    Knoxville (TYS)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 22 hours ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    Charleston, SC (CHS)to

    Knoxville (TYS)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $273Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Charleston, SC to Knoxville

    Looking for lower fares on your trip from Charleston, SC to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Charleston, SC to Knoxville