American Airlines flights from Des Moines to Knoxville

Recent searches for flights from Des Moines to Knoxville

Aug 2026
From$329*
Updated: 8 hours ago
Round tripIEconomy
Sep 2026
From$288*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$329*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $329
cmp-daily-histogram-bars-legend-max-price-aria-label $863
Displaying fares for August-2026
  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Sa

    AUG

  • DSM–TYS, 08/02/26 – 08/09/26: From $687
    02

    Su

  • DSM–TYS, 08/03/26 – 08/10/26: From $863
    03

    Mo

  • DSM–TYS, 08/04/26 – 08/11/26: From $687
    04

    Tu

  • DSM–TYS, 08/05/26 – 08/12/26: From $702
    05

    We

  • DSM–TYS, 08/06/26 – 08/13/26: From $702
    06

    Th

  • DSM–TYS, 08/07/26 – 08/14/26: From $702
    07

    Fr

  • DSM–TYS, 08/08/26 – 08/15/26: From $587
    08

    Sa

  • DSM–TYS, 08/09/26 – 08/16/26: From $642
    09

    Su

  • DSM–TYS, 08/10/26 – 08/17/26: From $587
    10

    Mo

  • DSM–TYS, 08/11/26 – 08/18/26: From $587
    11

    Tu

  • DSM–TYS, 08/12/26 – 08/19/26: From $587
    12

    We

  • DSM–TYS, 08/13/26 – 08/20/26: From $602
    13

    Th

  • DSM–TYS, 08/14/26 – 08/21/26: From $602
    14

    Fr

  • DSM–TYS, 08/15/26 – 08/22/26: From $388
    15

    Sa

  • DSM–TYS, 08/16/26 – 08/23/26: From $556
    16

    Su

  • DSM–TYS, 08/17/26 – 08/24/26: From $388
    17

    Mo

  • DSM–TYS, 08/18/26 – 08/25/26: From $388
    18

    Tu

  • DSM–TYS, 08/19/26 – 08/26/26: From $388
    19

    We

  • DSM–TYS, 08/20/26 – 08/27/26: From $388
    20

    Th

  • DSM–TYS, 08/21/26 – 08/28/26: From $398
    21

    Fr

  • DSM–TYS, 08/22/26 – 08/29/26: From $329
    22

    Sa

  • DSM–TYS, 08/23/26 – 08/30/26: From $407
    23

    Su

  • DSM–TYS, 08/24/26 – 08/31/26: From $329
    24

    Mo

  • DSM–TYS, 08/25/26 – 09/01/26: From $329
    25

    Tu

  • DSM–TYS, 08/26/26 – 09/02/26: From $329
    26

    We

  • DSM–TYS, 08/27/26 – 09/03/26: From $329
    27

    Th

  • DSM–TYS, 08/28/26 – 09/04/26: From $349
    28

    Fr

  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Sa

  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Su

  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    31

    Mo

    • range$329-$863

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Knoxville flights

    $
    keyboard_arrow_down

    Des Moines (DSM)to

    Knoxville (TYS)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $288Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/02/26 - 09/09/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/10/26 - 09/17/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/11/26 - 09/18/26

    Round trip

    Economy

    from
    $318Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $329Fare subject to changes
    Updated: 8 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $329Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Knoxville

    Looking for lower fares on your trip from Des Moines to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Knoxville