American Airlines flights from Des Moines to Knoxville

Recent searches for flights from Des Moines to Knoxville

Aug 2026
From$532*
Updated: 10 hours ago
Round tripIEconomy
Sep 2026
From$287*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$287*
Updated: 10 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $287
cmp-daily-histogram-bars-legend-max-price-aria-label $682
Displaying fares for August-2026
  • DSM–TYS, 08/22/26 – 08/29/26: From $682
    22

    Sa

    AUG

  • DSM–TYS, 08/23/26 – 08/30/26: From $682
    23

    Su

  • DSM–TYS, 08/24/26 – 08/31/26: From $682
    24

    Mo

  • DSM–TYS, 08/25/26 – 09/01/26: From $682
    25

    Tu

  • DSM–TYS, 08/26/26 – 09/02/26: From $682
    26

    We

  • DSM–TYS, 08/27/26 – 09/03/26: From $682
    27

    Th

  • DSM–TYS, 08/28/26 – 09/04/26: From $682
    28

    Fr

  • DSM–TYS, 08/29/26 – 09/05/26: From $532
    29

    Sa

  • DSM–TYS, 08/30/26 – 09/06/26: From $582
    30

    Su

  • DSM–TYS, 08/31/26 – 09/07/26: From $682
    31

    Mo

  • DSM–TYS, 09/01/26 – 09/08/26: From $532
    01

    Tu

    SEP

  • DSM–TYS, 09/02/26 – 09/09/26: From $532
    02

    We

  • DSM–TYS, 09/03/26 – 09/10/26: From $582
    03

    Th

  • DSM–TYS, 09/04/26 – 09/11/26: From $582
    04

    Fr

  • DSM–TYS, 09/05/26 – 09/12/26: From $287
    05

    Sa

  • DSM–TYS, 09/06/26 – 09/13/26: From $417
    06

    Su

  • DSM–TYS, 09/07/26 – 09/14/26: From $367
    07

    Mo

  • DSM–TYS, 09/08/26 – 09/15/26: From $317
    08

    Tu

  • DSM–TYS, 09/09/26 – 09/16/26: From $287
    09

    We

  • DSM–TYS, 09/10/26 – 09/17/26: From $287
    10

    Th

  • DSM–TYS, 09/11/26 – 09/18/26: From $308
    11

    Fr

  • DSM–TYS, 09/12/26 – 09/19/26: From $287
    12

    Sa

  • DSM–TYS, 09/13/26 – 09/20/26: From $586
    13

    Su

  • DSM–TYS, 09/14/26 – 09/21/26: From $287
    14

    Mo

  • DSM–TYS, 09/15/26 – 09/22/26: From $287
    15

    Tu

  • DSM–TYS, 09/16/26 – 09/23/26: From $287
    16

    We

  • DSM–TYS, 09/17/26 – 09/24/26: From $491
    17

    Th

  • DSM–TYS, 09/18/26 – 09/25/26: From $434
    18

    Fr

  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Sa

  • DSM–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Su

  • DSM–TYS, 09/21/26 – 09/28/26: From $287
    21

    Mo

    • range$287-$682

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Knoxville flights

    $
    keyboard_arrow_down

    Des Moines (DSM)to

    Knoxville (TYS)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/21/26 - 09/28/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 19 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    09/16/26 - 09/23/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    Des Moines (DSM)to

    Knoxville (TYS)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $287Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Knoxville

    Looking for lower fares on your trip from Des Moines to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Knoxville