American Airlines flights from Syracuse to Knoxville

Recent searches for flights from Syracuse to Knoxville

Sep 2026
From$354*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$307*
Updated: 1 hour ago
Round tripIEconomy
Nov 2026
From$307*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $339
cmp-daily-histogram-bars-legend-max-price-aria-label $1.0K
Displaying fares for September-2026
  • SYR–TYS, 09/12/26 – 09/19/26: From $383
    12

    Sa

    SEP

  • SYR–TYS, 09/13/26 – 09/20/26: From $627
    13

    Su

  • SYR–TYS, 09/14/26 – 09/21/26: From $475
    14

    Mo

  • SYR–TYS, 09/15/26 – 09/22/26: From $383
    15

    Tu

  • SYR–TYS, 09/16/26 – 09/23/26: From $383
    16

    We

  • SYR–TYS, 09/17/26 – 09/24/26: From $485
    17

    Th

  • SYR–TYS, 09/18/26 – 09/25/26: From $572
    18

    Fr

  • SYR–TYS, 09/19/26 – 09/26/26: From $376
    19

    Sa

  • SYR–TYS, 09/20/26 – 09/27/26: From $1,003
    20

    Su

  • SYR–TYS, 09/21/26 – 09/28/26: From $399
    21

    Mo

  • SYR–TYS, 09/22/26 – 09/29/26: From $376
    22

    Tu

  • SYR–TYS, 09/23/26 – 09/30/26: From $376
    23

    We

  • SYR–TYS, 09/24/26 – 10/01/26: From $542
    24

    Th

  • SYR–TYS, 09/25/26 – 09/26/26: From $777
    25

    Fr

  • SYR–TYS, 09/26/26 – 10/03/26: From $528
    26

    Sa

  • SYR–TYS, 09/27/26 – 10/04/26: From $873
    27

    Su

  • SYR–TYS, 09/28/26 – 10/05/26: From $424
    28

    Mo

  • SYR–TYS, 09/29/26 – 10/06/26: From $354
    29

    Tu

  • SYR–TYS, 09/30/26 – 10/07/26: From $354
    30

    We

  • SYR–TYS, 10/01/26 – 10/08/26: From $394
    01

    Th

    OCT

  • SYR–TYS, 10/02/26 – 10/09/26: From $394
    02

    Fr

  • SYR–TYS, 10/03/26 – 10/10/26: From $339
    03

    Sa

  • SYR–TYS, 10/04/26 – 10/11/26: From $419
    04

    Su

  • SYR–TYS, 10/05/26 – 10/12/26: From $415
    05

    Mo

  • SYR–TYS, 10/06/26 – 10/13/26: From $513
    06

    Tu

  • SYR–TYS, 10/07/26 – 10/14/26: From $364
    07

    We

  • SYR–TYS, 10/08/26 – 10/15/26: From $647
    08

    Th

  • SYR–TYS, 10/09/26 – 10/16/26: From $858
    09

    Fr

  • SYR–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Sa

  • SYR–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Su

    • range$339-$1,003

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Syracuse to Knoxville flights

    $
    keyboard_arrow_down

    Syracuse (SYR)to

    Knoxville (TYS)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    Syracuse (SYR)to

    Knoxville (TYS)
    11/24/26 - 12/01/26

    Round trip

    Economy

    from
    $307Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Syracuse to Knoxville

    Looking for lower fares on your trip from Syracuse to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Syracuse to Knoxville