American Airlines flights from Santa Fe to Knoxville

Recent searches for flights from Santa Fe to Knoxville

Aug 2026
From$439*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$334*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$334*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $334
cmp-daily-histogram-bars-legend-max-price-aria-label $779
Displaying fares for August-2026
  • SAF–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Fr

    AUG

  • SAF–TYS, 08/22/26 – 08/29/26: From $496
    22

    Sa

  • SAF–TYS, 08/23/26 – 08/30/26: From $504
    23

    Su

  • SAF–TYS, 08/24/26 – 08/31/26: From $504
    24

    Mo

  • SAF–TYS, 08/25/26 – 09/01/26: From $496
    25

    Tu

  • SAF–TYS, 08/26/26 – 09/02/26: From $496
    26

    We

  • SAF–TYS, 08/27/26 – 09/03/26: From $534
    27

    Th

  • SAF–TYS, 08/28/26 – 09/04/26: From $439
    28

    Fr

  • SAF–TYS, 08/29/26 – 09/05/26: From $439
    29

    Sa

  • SAF–TYS, 08/30/26 – 09/06/26: From $510
    30

    Su

  • SAF–TYS, 08/31/26 – 09/07/26: From $545
    31

    Mo

  • SAF–TYS, 09/01/26 – 09/08/26: From $623
    01

    Tu

    SEP

  • SAF–TYS, 09/02/26 – 09/09/26: From $439
    02

    We

  • SAF–TYS, 09/03/26 – 09/10/26: From $469
    03

    Th

  • SAF–TYS, 09/04/26 – 09/11/26: From $584
    04

    Fr

  • SAF–TYS, 09/05/26 – 09/12/26: From $369
    05

    Sa

  • SAF–TYS, 09/06/26 – 09/13/26: From $651
    06

    Su

  • SAF–TYS, 09/07/26 – 09/14/26: From $752
    07

    Mo

  • SAF–TYS, 09/08/26 – 09/15/26: From $426
    08

    Tu

  • SAF–TYS, 09/09/26 – 09/16/26: From $369
    09

    We

  • SAF–TYS, 09/10/26 – 09/17/26: From $510
    10

    Th

  • SAF–TYS, 09/11/26 – 09/18/26: From $369
    11

    Fr

  • SAF–TYS, 09/12/26 – 09/19/26: From $334
    12

    Sa

  • SAF–TYS, 09/13/26 – 09/20/26: From $779
    13

    Su

  • SAF–TYS, 09/14/26 – 09/21/26: From $575
    14

    Mo

  • SAF–TYS, 09/15/26 – 09/22/26: From $334
    15

    Tu

  • SAF–TYS, 09/16/26 – 09/23/26: From $461
    16

    We

  • SAF–TYS, 09/17/26 – 09/24/26: From $616
    17

    Th

  • SAF–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Fr

  • SAF–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Sa

  • SAF–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Su

    • range$334-$779

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Santa Fe to Knoxville flights

    $
    keyboard_arrow_down

    Santa Fe (SAF)to

    Knoxville (TYS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    Santa Fe (SAF)to

    Knoxville (TYS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $334Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Santa Fe to Knoxville

    Looking for lower fares on your trip from Santa Fe to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Santa Fe to Knoxville