American Airlines flights from Saint Louis to Knoxville

Recent searches for flights from Saint Louis to Knoxville

Sep 2026
From$396*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$309*
Updated: 4 hours ago
Round tripIEconomy
Nov 2026
From$309*
Updated: 4 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $317
cmp-daily-histogram-bars-legend-max-price-aria-label $952
Displaying fares for September-2026
  • STL–TYS, 09/13/26 – 09/20/26: From $663
    13

    Su

    SEP

  • STL–TYS, 09/14/26 – 09/21/26: From $663
    14

    Mo

  • STL–TYS, 09/15/26 – 09/22/26: From $541
    15

    Tu

  • STL–TYS, 09/16/26 – 09/23/26: From $541
    16

    We

  • STL–TYS, 09/17/26 – 09/24/26: From $663
    17

    Th

  • STL–TYS, 09/18/26 – 09/25/26: From $663
    18

    Fr

  • STL–TYS, 09/19/26 – 09/26/26: From $541
    19

    Sa

  • STL–TYS, 09/20/26 – 09/27/26: From $952
    20

    Su

  • STL–TYS, 09/21/26 – 09/28/26: From $597
    21

    Mo

  • STL–TYS, 09/22/26 – 09/29/26: From $504
    22

    Tu

  • STL–TYS, 09/23/26 – 09/30/26: From $504
    23

    We

  • STL–TYS, 09/24/26 – 10/01/26: From $652
    24

    Th

  • STL–TYS, 09/25/26 – 10/02/26: From $785
    25

    Fr

  • STL–TYS, 09/26/26 – 10/03/26: From $504
    26

    Sa

  • STL–TYS, 09/27/26 – 10/04/26: From $711
    27

    Su

  • STL–TYS, 09/28/26 – 10/05/26: From $396
    28

    Mo

  • STL–TYS, 09/29/26 – 10/06/26: From $396
    29

    Tu

  • STL–TYS, 09/30/26 – 10/07/26: From $396
    30

    We

  • STL–TYS, 10/01/26 – 10/08/26: From $396
    01

    Th

    OCT

  • STL–TYS, 10/02/26 – 10/09/26: From $396
    02

    Fr

  • STL–TYS, 10/03/26 – 10/10/26: From $396
    03

    Sa

  • STL–TYS, 10/04/26 – 10/11/26: From $387
    04

    Su

  • STL–TYS, 10/05/26 – 10/12/26: From $325
    05

    Mo

  • STL–TYS, 10/06/26 – 10/13/26: From $374
    06

    Tu

  • STL–TYS, 10/07/26 – 10/14/26: From $317
    07

    We

  • STL–TYS, 10/08/26 – 10/15/26: From $518
    08

    Th

  • STL–TYS, 10/09/26 – 10/16/26: From $518
    09

    Fr

  • STL–TYS, 10/10/26 – 10/17/26: From $497
    10

    Sa

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Su

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

    • range$317-$952

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Saint Louis to Knoxville flights

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    Saint Louis (STL)to

    Knoxville (TYS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    12/03/26 - 12/10/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    Saint Louis (STL)to

    Knoxville (TYS)
    11/02/26 - 11/09/26

    Round trip

    Economy

    from
    $309Fare subject to changes
    Updated: 4 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Saint Louis to Knoxville

    Looking for lower fares on your trip from Saint Louis to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Saint Louis to Knoxville