American Airlines flights from Myrtle Beach to Knoxville

Recent searches for flights from Myrtle Beach to Knoxville

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Mar 2026
No results available
Apr 2026
From$521*
Updated: 23 hours ago
Round tripIEconomy
May 2026
From$318*
Updated: 11 hours ago
Round tripIEconomy
$521
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    • range$521-$530

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Myrtle Beach to Knoxville flights

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    Myrtle Beach (MYR)to

    Knoxville (TYS)
    05/11/26 - 05/15/26

    Round trip

    Economy

    from
    $318Fare subject to changes
    Updated: 11 hours ago

    Myrtle Beach (MYR)to

    Knoxville (TYS)
    05/30/26 - 06/02/26

    Round trip

    Economy

    from
    $472Fare subject to changes
    Updated: 20 hours ago

    Myrtle Beach (MYR)to

    Knoxville (TYS)
    04/08/26 - 04/09/26

    Round trip

    Economy

    from
    $521Fare subject to changes
    Updated: 23 hours ago

    Myrtle Beach (MYR)to

    Knoxville (TYS)
    04/02/26 - 04/07/26

    Round trip

    Economy

    from
    $530Fare subject to changes
    Updated: 18 hours ago

    Myrtle Beach (MYR)to

    Knoxville (TYS)
    05/31/26 - 06/02/26

    Round trip

    Economy

    from
    $575Fare subject to changes
    Updated: 20 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    American Airlines flights from Myrtle Beach to Knoxville

    Earn up to $400 back on your next American Airlines flight plus, 30,000 bonus miles. Terms apply. Opens another site in a new window that may not meet accessibility guidelines.