American Airlines flights from Portland, ME to San Francisco

Recent searches for flights from Portland, ME to San Francisco

Sep 2026
From$459*
Updated: 16 hours ago
Round tripIEconomy
Oct 2026
From$419*
Updated: 16 hours ago
Round tripIEconomy
Nov 2026
From$419*
Updated: 16 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $443
cmp-daily-histogram-bars-legend-max-price-aria-label $875
Displaying fares for September-2026
  • PWM–SFO, 09/15/26 – 09/22/26: From $581
    15

    Tu

    SEP

  • PWM–SFO, 09/16/26 – 09/23/26: From $615
    16

    We

  • PWM–SFO, 09/17/26 – 09/24/26: From $825
    17

    Th

  • PWM–SFO, 09/18/26 – 09/25/26: From $615
    18

    Fr

  • PWM–SFO, 09/19/26 – 09/26/26: From $581
    19

    Sa

  • PWM–SFO, 09/20/26 – 09/27/26: From $825
    20

    Su

  • PWM–SFO, 09/21/26 – 09/28/26: From $813
    21

    Mo

  • PWM–SFO, 09/22/26 – 09/29/26: From $574
    22

    Tu

  • PWM–SFO, 09/23/26 – 09/30/26: From $574
    23

    We

  • PWM–SFO, 09/24/26 – 10/01/26: From $875
    24

    Th

  • PWM–SFO, 09/25/26 – 10/02/26: From $675
    25

    Fr

  • PWM–SFO, 09/26/26 – 10/03/26: From $540
    26

    Sa

  • PWM–SFO, 09/27/26 – 10/04/26: From $784
    27

    Su

  • PWM–SFO, 09/28/26 – 10/05/26: From $743
    28

    Mo

  • PWM–SFO, 09/29/26 – 10/06/26: From $459
    29

    Tu

  • PWM–SFO, 09/30/26 – 10/07/26: From $459
    30

    We

  • PWM–SFO, 10/01/26 – 10/08/26: From $830
    01

    Th

    OCT

  • PWM–SFO, 10/02/26 – 10/09/26: From $634
    02

    Fr

  • PWM–SFO, 10/03/26 – 10/10/26: From $459
    03

    Sa

  • PWM–SFO, 10/04/26 – 10/11/26: From $743
    04

    Su

  • PWM–SFO, 10/05/26 – 10/12/26: From $618
    05

    Mo

  • PWM–SFO, 10/06/26 – 10/13/26: From $558
    06

    Tu

  • PWM–SFO, 10/07/26 – 10/14/26: From $443
    07

    We

  • PWM–SFO, 10/08/26 – 10/15/26: From $858
    08

    Th

  • PWM–SFO, 10/09/26 – 10/16/26: From $663
    09

    Fr

  • PWM–SFO, 10/10/26 – 10/17/26: From $594
    10

    Sa

  • PWM–SFO, 10/11/26 – 10/18/26: From $833
    11

    Su

  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    13

    Tu

  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    14

    We

    • range$443-$875

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Portland, ME to San Francisco flights

    $
    keyboard_arrow_down

    Portland, ME (PWM)to

    San Francisco (SFO)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    11/18/26 - 11/25/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    11/01/26 - 11/08/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    11/06/26 - 11/13/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $419Fare subject to changes
    Updated: 16 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Portland, ME to San Francisco

    Looking for lower fares on your trip from Portland, ME to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    American Airlines flights from Portland, ME to San Francisco