American Airlines flights from Portland, ME to San Francisco

Recent searches for flights from Portland, ME to San Francisco

Aug 2026
From$379*
Updated: 3 hours ago
Round tripIEconomy
Sep 2026
From$379*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$379*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $379
cmp-daily-histogram-bars-legend-max-price-aria-label $1.3K
Displaying fares for August-2026
  • PWM–SFO, 08/05/26 – 08/12/26: From $898
    05

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    AUG

  • PWM–SFO, 08/06/26 – 08/13/26: From $922
    06

    Th

  • PWM–SFO, 08/07/26 – 08/14/26: From $1,060
    07

    Fr

  • PWM–SFO, 08/08/26 – 08/15/26: From $833
    08

    Sa

  • PWM–SFO, 08/09/26 – 08/16/26: From $1,326
    09

    Su

  • PWM–SFO, 08/10/26 – 08/17/26: From $1,200
    10

    Mo

  • PWM–SFO, 08/11/26 – 08/18/26: From $833
    11

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  • PWM–SFO, 08/12/26 – 08/19/26: From $524
    12

    We

  • PWM–SFO, 08/13/26 – 08/20/26: From $883
    13

    Th

  • PWM–SFO, 08/14/26 – 08/21/26: From $673
    14

    Fr

  • PWM–SFO, 08/15/26 – 08/22/26: From $579
    15

    Sa

  • PWM–SFO, 08/16/26 – 08/23/26: From $833
    16

    Su

  • PWM–SFO, 08/17/26 – 08/24/26: From $608
    17

    Mo

  • PWM–SFO, 08/18/26 – 08/25/26: From $419
    18

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  • PWM–SFO, 08/19/26 – 08/26/26: From $419
    19

    We

  • PWM–SFO, 08/20/26 – 08/27/26: From $419
    20

    Th

  • PWM–SFO, 08/21/26 – 08/28/26: From $419
    21

    Fr

  • PWM–SFO, 08/22/26 – 08/29/26: From $419
    22

    Sa

  • PWM–SFO, 08/23/26 – 08/30/26: From $419
    23

    Su

  • PWM–SFO, 08/24/26 – 08/31/26: From $469
    24

    Mo

  • PWM–SFO, 08/25/26 – 09/01/26: From $379
    25

    Tu

  • PWM–SFO, 08/26/26 – 09/02/26: From $379
    26

    We

  • PWM–SFO, 08/27/26 – 09/03/26: From $568
    27

    Th

  • PWM–SFO, 08/28/26 – 09/04/26: From $460
    28

    Fr

  • PWM–SFO, 08/29/26 – 09/05/26: From $379
    29

    Sa

  • PWM–SFO, 08/30/26 – 09/06/26: From $379
    30

    Su

  • PWM–SFO, 08/31/26 – 09/07/26: From $379
    31

    Mo

  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    01

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    SEP

  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    02

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  • PWM–SFO: cmp-view-offers-disclaimer. Find Offers
    03

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  • PWM–SFO, 09/04/26 – 09/11/26: From $379
    04

    Fr

    • range$379-$1,326

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Portland, ME to San Francisco flights

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    Portland, ME (PWM)to

    San Francisco (SFO)
    10/15/26 - 10/22/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    10/26/26 - 11/02/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    08/26/26 - 09/02/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    Portland, ME (PWM)to

    San Francisco (SFO)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $379Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Portland, ME to San Francisco

    Looking for lower fares on your trip from Portland, ME to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Portland, ME to San Francisco