American Airlines flights from Destin to Indianapolis

Recent searches for flights from Destin to Indianapolis

Sep 2026
From$341*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$341*
Updated: 10 hours ago
Round tripIEconomy
Nov 2026
From$341*
Updated: 10 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $341
cmp-daily-histogram-bars-legend-max-price-aria-label $1.1K
Displaying fares for September-2026
  • VPS–IND: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

    SEP

  • VPS–IND, 09/05/26 – 09/12/26: From $675
    05

    Sa

  • VPS–IND, 09/06/26 – 09/13/26: From $675
    06

    Su

  • VPS–IND, 09/07/26 – 09/14/26: From $1,061
    07

    Mo

  • VPS–IND, 09/08/26 – 09/15/26: From $675
    08

    Tu

  • VPS–IND, 09/09/26 – 09/16/26: From $675
    09

    We

  • VPS–IND, 09/10/26 – 09/17/26: From $675
    10

    Th

  • VPS–IND, 09/11/26 – 09/18/26: From $546
    11

    Fr

  • VPS–IND, 09/12/26 – 09/19/26: From $546
    12

    Sa

  • VPS–IND, 09/13/26 – 09/20/26: From $676
    13

    Su

  • VPS–IND, 09/14/26 – 09/21/26: From $546
    14

    Mo

  • VPS–IND, 09/15/26 – 09/22/26: From $546
    15

    Tu

  • VPS–IND, 09/16/26 – 09/23/26: From $546
    16

    We

  • VPS–IND, 09/17/26 – 09/24/26: From $546
    17

    Th

  • VPS–IND, 09/18/26 – 09/25/26: From $384
    18

    Fr

  • VPS–IND, 09/19/26 – 09/26/26: From $384
    19

    Sa

  • VPS–IND, 09/20/26 – 09/27/26: From $565
    20

    Su

  • VPS–IND, 09/21/26 – 09/28/26: From $384
    21

    Mo

  • VPS–IND, 09/22/26 – 09/29/26: From $384
    22

    Tu

  • VPS–IND, 09/23/26 – 09/30/26: From $586
    23

    We

  • VPS–IND, 09/24/26 – 10/01/26: From $384
    24

    Th

  • VPS–IND, 09/25/26 – 10/02/26: From $341
    25

    Fr

  • VPS–IND, 09/26/26 – 10/03/26: From $341
    26

    Sa

  • VPS–IND, 09/27/26 – 10/04/26: From $451
    27

    Su

  • VPS–IND, 09/28/26 – 10/05/26: From $341
    28

    Mo

  • VPS–IND, 09/29/26 – 10/06/26: From $341
    29

    Tu

  • VPS–IND, 09/30/26 – 10/07/26: From $341
    30

    We

  • VPS–IND, 10/01/26 – 10/08/26: From $565
    01

    Th

    OCT

  • VPS–IND: cmp-view-offers-disclaimer. Find Offers
    02

    Fr

  • VPS–IND: cmp-view-offers-disclaimer. Find Offers
    03

    Sa

    • range$341-$1,061

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Destin to Indianapolis flights

    $
    keyboard_arrow_down

    Destin (VPS)to

    Indianapolis (IND)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    10/29/26 - 11/05/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    09/25/26 - 10/02/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Destin (VPS)to

    Indianapolis (IND)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Destin to Indianapolis

    Looking for lower fares on your trip from Destin to Indianapolis? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Destin to Indianapolis