American Airlines flights from Destin to San Francisco

Recent searches for flights from Destin to San Francisco

Sep 2026
From$450*
Updated: 6 hours ago
Round tripIEconomy
Oct 2026
From$367*
Updated: 6 hours ago
Round tripIEconomy
Nov 2026
From$367*
Updated: 6 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $367
cmp-daily-histogram-bars-legend-max-price-aria-label $856
Displaying fares for September-2026
  • VPS–SFO: cmp-view-offers-disclaimer. Find Offers
    10

    Th

    SEP

  • VPS–SFO, 09/11/26 – 09/18/26: From $701
    11

    Fr

  • VPS–SFO, 09/12/26 – 09/19/26: From $533
    12

    Sa

  • VPS–SFO, 09/13/26 – 09/20/26: From $850
    13

    Su

  • VPS–SFO, 09/14/26 – 09/21/26: From $856
    14

    Mo

  • VPS–SFO, 09/15/26 – 09/22/26: From $533
    15

    Tu

  • VPS–SFO, 09/16/26 – 09/23/26: From $533
    16

    We

  • VPS–SFO, 09/17/26 – 09/24/26: From $645
    17

    Th

  • VPS–SFO, 09/18/26 – 09/25/26: From $645
    18

    Fr

  • VPS–SFO, 09/19/26 – 09/26/26: From $533
    19

    Sa

  • VPS–SFO, 09/20/26 – 09/27/26: From $691
    20

    Su

  • VPS–SFO, 09/21/26 – 09/28/26: From $645
    21

    Mo

  • VPS–SFO, 09/22/26 – 09/29/26: From $533
    22

    Tu

  • VPS–SFO, 09/23/26 – 09/30/26: From $533
    23

    We

  • VPS–SFO, 09/24/26 – 10/01/26: From $621
    24

    Th

  • VPS–SFO, 09/25/26 – 10/02/26: From $499
    25

    Fr

  • VPS–SFO, 09/26/26 – 10/03/26: From $450
    26

    Sa

  • VPS–SFO, 09/27/26 – 10/04/26: From $571
    27

    Su

  • VPS–SFO, 09/28/26 – 10/05/26: From $537
    28

    Mo

  • VPS–SFO, 09/29/26 – 10/06/26: From $450
    29

    Tu

  • VPS–SFO, 09/30/26 – 10/07/26: From $450
    30

    We

  • VPS–SFO, 10/01/26 – 10/08/26: From $531
    01

    Th

    OCT

  • VPS–SFO, 10/02/26 – 10/09/26: From $499
    02

    Fr

  • VPS–SFO, 10/03/26 – 10/10/26: From $367
    03

    Sa

  • VPS–SFO, 10/04/26 – 10/11/26: From $641
    04

    Su

  • VPS–SFO, 10/05/26 – 10/12/26: From $385
    05

    Mo

  • VPS–SFO, 10/06/26 – 10/13/26: From $367
    06

    Tu

  • VPS–SFO, 10/07/26 – 10/14/26: From $367
    07

    We

  • VPS–SFO: cmp-view-offers-disclaimer. Find Offers
    08

    Th

  • VPS–SFO: cmp-view-offers-disclaimer. Find Offers
    09

    Fr

    • range$367-$856

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Destin to San Francisco flights

    $
    keyboard_arrow_down

    Destin (VPS)to

    San Francisco (SFO)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    10/22/26 - 10/29/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    Destin (VPS)to

    San Francisco (SFO)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $367Fare subject to changes
    Updated: 6 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Destin to San Francisco

    Looking for lower fares on your trip from Destin to San Francisco? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Citi / AAdvantage credit card offer.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Destin to San Francisco