American Airlines flights from Columbus to Saint Louis

Recent searches for flights from Columbus to Saint Louis

Aug 2026
From$269*
Updated: 8 hours ago
Round tripIEconomy
Sep 2026
From$269*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$281*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $269
cmp-daily-histogram-bars-legend-max-price-aria-label $453
Displaying fares for August-2026
  • CMH–STL: cmp-view-offers-disclaimer. Find Offers
    05

    We

    AUG

  • CMH–STL, 08/06/26 – 08/13/26: From $387
    06

    Th

  • CMH–STL, 08/07/26 – 08/14/26: From $387
    07

    Fr

  • CMH–STL, 08/08/26 – 08/15/26: From $387
    08

    Sa

  • CMH–STL, 08/09/26 – 08/16/26: From $453
    09

    Su

  • CMH–STL, 08/10/26 – 08/17/26: From $387
    10

    Mo

  • CMH–STL, 08/11/26 – 08/18/26: From $371
    11

    Tu

  • CMH–STL, 08/12/26 – 08/19/26: From $371
    12

    We

  • CMH–STL, 08/13/26 – 08/20/26: From $381
    13

    Th

  • CMH–STL, 08/14/26 – 08/21/26: From $381
    14

    Fr

  • CMH–STL, 08/15/26 – 08/22/26: From $381
    15

    Sa

  • CMH–STL, 08/16/26 – 08/23/26: From $381
    16

    Su

  • CMH–STL, 08/17/26 – 08/24/26: From $381
    17

    Mo

  • CMH–STL, 08/18/26 – 08/25/26: From $371
    18

    Tu

  • CMH–STL, 08/19/26 – 08/26/26: From $308
    19

    We

  • CMH–STL, 08/20/26 – 08/27/26: From $308
    20

    Th

  • CMH–STL, 08/21/26 – 08/28/26: From $335
    21

    Fr

  • CMH–STL, 08/22/26 – 08/29/26: From $308
    22

    Sa

  • CMH–STL, 08/23/26 – 08/30/26: From $335
    23

    Su

  • CMH–STL, 08/24/26 – 08/31/26: From $308
    24

    Mo

  • CMH–STL, 08/25/26 – 09/01/26: From $308
    25

    Tu

  • CMH–STL, 08/26/26 – 09/02/26: From $281
    26

    We

  • CMH–STL, 08/27/26 – 09/03/26: From $281
    27

    Th

  • CMH–STL, 08/28/26 – 08/31/26: From $308
    28

    Fr

  • CMH–STL, 08/29/26 – 09/05/26: From $269
    29

    Sa

  • CMH–STL, 08/30/26 – 09/06/26: From $299
    30

    Su

  • CMH–STL, 08/31/26 – 09/07/26: From $330
    31

    Mo

  • CMH–STL, 09/01/26 – 09/08/26: From $281
    01

    Tu

    SEP

  • CMH–STL: cmp-view-offers-disclaimer. Find Offers
    02

    We

  • CMH–STL, 09/03/26 – 09/13/26: From $308
    03

    Th

  • CMH–STL: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

    • range$269-$453

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Columbus to Saint Louis flights

    $
    keyboard_arrow_down

    Columbus (CMH)to

    Saint Louis (STL)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    Columbus (CMH)to

    Saint Louis (STL)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $281Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Columbus to Saint Louis

    Looking for lower fares on your trip from Columbus to Saint Louis? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Columbus to Saint Louis