American Airlines flights from Des Moines to Buffalo

Recent searches for flights from Des Moines to Buffalo

Aug 2026
From$801*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$325*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$325*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $325
cmp-daily-histogram-bars-legend-max-price-aria-label $892
Displaying fares for August-2026
  • DSM–BUF: cmp-view-offers-disclaimer. Find Offers
    25

    Tu

    AUG

  • DSM–BUF, 08/26/26 – 09/02/26: From $801
    26

    We

  • DSM–BUF, 08/27/26 – 09/03/26: From $879
    27

    Th

  • DSM–BUF, 08/28/26 – 09/04/26: From $892
    28

    Fr

  • DSM–BUF, 08/29/26 – 09/05/26: From $801
    29

    Sa

  • DSM–BUF, 08/30/26 – 09/06/26: From $879
    30

    Su

  • DSM–BUF, 08/31/26 – 09/07/26: From $892
    31

    Mo

  • DSM–BUF, 09/01/26 – 09/08/26: From $673
    01

    Tu

    SEP

  • DSM–BUF, 09/02/26 – 09/09/26: From $673
    02

    We

  • DSM–BUF, 09/03/26 – 09/10/26: From $673
    03

    Th

  • DSM–BUF, 09/04/26 – 09/11/26: From $673
    04

    Fr

  • DSM–BUF, 09/05/26 – 09/12/26: From $411
    05

    Sa

  • DSM–BUF, 09/06/26 – 09/13/26: From $416
    06

    Su

  • DSM–BUF, 09/07/26 – 09/14/26: From $673
    07

    Mo

  • DSM–BUF, 09/08/26 – 09/15/26: From $411
    08

    Tu

  • DSM–BUF, 09/09/26 – 09/16/26: From $325
    09

    We

  • DSM–BUF, 09/10/26 – 09/17/26: From $325
    10

    Th

  • DSM–BUF, 09/11/26 – 09/18/26: From $381
    11

    Fr

  • DSM–BUF, 09/12/26 – 09/19/26: From $325
    12

    Sa

  • DSM–BUF, 09/13/26 – 09/17/26: From $411
    13

    Su

  • DSM–BUF, 09/14/26 – 09/21/26: From $411
    14

    Mo

  • DSM–BUF, 09/15/26 – 09/22/26: From $325
    15

    Tu

  • DSM–BUF, 09/16/26 – 09/23/26: From $330
    16

    We

  • DSM–BUF, 09/17/26 – 09/24/26: From $415
    17

    Th

  • DSM–BUF, 09/18/26 – 09/25/26: From $365
    18

    Fr

  • DSM–BUF, 09/19/26 – 09/26/26: From $325
    19

    Sa

  • DSM–BUF, 09/20/26 – 09/27/26: From $447
    20

    Su

  • DSM–BUF, 09/21/26 – 09/28/26: From $457
    21

    Mo

  • DSM–BUF: cmp-view-offers-disclaimer. Find Offers
    22

    Tu

  • DSM–BUF: cmp-view-offers-disclaimer. Find Offers
    23

    We

  • DSM–BUF: cmp-view-offers-disclaimer. Find Offers
    24

    Th

    • range$325-$892

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Des Moines to Buffalo flights

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    Des Moines (DSM)to

    Buffalo (BUF)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    11/05/26 - 11/12/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    10/26/26 - 11/02/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    Des Moines (DSM)to

    Buffalo (BUF)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $325Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Des Moines to Buffalo

    Looking for lower fares on your trip from Des Moines to Buffalo? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Des Moines to Buffalo