American Airlines flights from Knoxville to Myrtle Beach

Recent searches for flights from Knoxville to Myrtle Beach

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Jul 2026
No results available
Aug 2026
From$247*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$221*
Updated: 7 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $247
cmp-daily-histogram-bars-legend-max-price-aria-label $697
Displaying fares for July-2026
  • TYS–MYR: cmp-view-offers-disclaimer. Find Offers
    31

    Fr

    JUL

  • TYS–MYR, 08/01/26 – 08/08/26: From $662
    01

    Sa

  • TYS–MYR, 08/02/26 – 08/09/26: From $697
    02

    Su

  • TYS–MYR, 08/03/26 – 08/10/26: From $662
    03

    Mo

  • TYS–MYR, 08/04/26 – 08/11/26: From $662
    04

    Tu

  • TYS–MYR, 08/05/26 – 08/12/26: From $662
    05

    We

  • TYS–MYR, 08/06/26 – 08/13/26: From $662
    06

    Th

  • TYS–MYR, 08/07/26 – 08/14/26: From $577
    07

    Fr

  • TYS–MYR, 08/08/26 – 08/15/26: From $621
    08

    Sa

  • TYS–MYR, 08/09/26 – 08/16/26: From $577
    09

    Su

  • TYS–MYR, 08/10/26 – 08/17/26: From $577
    10

    Mo

  • TYS–MYR, 08/11/26 – 08/18/26: From $577
    11

    Tu

  • TYS–MYR, 08/12/26 – 08/19/26: From $577
    12

    We

  • TYS–MYR, 08/13/26 – 08/20/26: From $577
    13

    Th

  • TYS–MYR, 08/14/26 – 08/21/26: From $372
    14

    Fr

  • TYS–MYR, 08/15/26 – 08/22/26: From $497
    15

    Sa

  • TYS–MYR, 08/16/26 – 08/23/26: From $417
    16

    Su

  • TYS–MYR, 08/17/26 – 08/24/26: From $347
    17

    Mo

  • TYS–MYR, 08/18/26 – 08/25/26: From $347
    18

    Tu

  • TYS–MYR, 08/19/26 – 08/26/26: From $347
    19

    We

  • TYS–MYR, 08/20/26 – 08/27/26: From $347
    20

    Th

  • TYS–MYR, 08/21/26 – 08/28/26: From $297
    21

    Fr

  • TYS–MYR, 08/22/26 – 08/29/26: From $247
    22

    Sa

  • TYS–MYR, 08/23/26 – 08/30/26: From $367
    23

    Su

  • TYS–MYR, 08/24/26 – 08/31/26: From $247
    24

    Mo

  • TYS–MYR, 08/25/26 – 09/01/26: From $247
    25

    Tu

  • TYS–MYR, 08/26/26 – 09/02/26: From $247
    26

    We

  • TYS–MYR, 08/27/26 – 09/03/26: From $317
    27

    Th

  • TYS–MYR: cmp-view-offers-disclaimer. Find Offers
    28

    Fr

  • TYS–MYR: cmp-view-offers-disclaimer. Find Offers
    29

    Sa

  • TYS–MYR: cmp-view-offers-disclaimer. Find Offers
    30

    Su

    • range$247-$697

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to Myrtle Beach flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    09/02/26 - 09/09/26

    Round trip

    Economy

    from
    $234Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $234Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $247Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $247Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $247Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    08/22/26 - 08/29/26

    Round trip

    Economy

    from
    $247Fare subject to changes
    Updated: 7 hours ago

    Knoxville (TYS)to

    Myrtle Beach (MYR)
    08/24/26 - 08/31/26

    Round trip

    Economy

    from
    $247Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to Myrtle Beach

    Looking for lower fares on your trip from Knoxville to Myrtle Beach? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to Myrtle Beach