American Airlines flights from Knoxville to Panama City

Recent searches for flights from Knoxville to Panama City

Aug 2026
From$256*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$269*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$266*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $256
cmp-daily-histogram-bars-legend-max-price-aria-label $719
Displaying fares for August-2026
  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    06

    Th

    AUG

  • TYS–ECP, 08/07/26 – 08/14/26: From $662
    07

    Fr

  • TYS–ECP, 08/08/26 – 08/15/26: From $662
    08

    Sa

  • TYS–ECP, 08/09/26 – 08/16/26: From $662
    09

    Su

  • TYS–ECP, 08/10/26 – 08/17/26: From $662
    10

    Mo

  • TYS–ECP, 08/11/26 – 08/18/26: From $662
    11

    Tu

  • TYS–ECP, 08/12/26 – 08/19/26: From $662
    12

    We

  • TYS–ECP, 08/13/26 – 08/20/26: From $577
    13

    Th

  • TYS–ECP, 08/14/26 – 08/21/26: From $577
    14

    Fr

  • TYS–ECP, 08/15/26 – 08/22/26: From $577
    15

    Sa

  • TYS–ECP, 08/16/26 – 08/23/26: From $617
    16

    Su

  • TYS–ECP, 08/17/26 – 08/24/26: From $577
    17

    Mo

  • TYS–ECP, 08/18/26 – 08/25/26: From $577
    18

    Tu

  • TYS–ECP, 08/19/26 – 08/26/26: From $577
    19

    We

  • TYS–ECP, 08/20/26 – 08/27/26: From $368
    20

    Th

  • TYS–ECP, 08/21/26 – 08/28/26: From $368
    21

    Fr

  • TYS–ECP, 08/22/26 – 08/29/26: From $358
    22

    Sa

  • TYS–ECP, 08/23/26 – 08/30/26: From $577
    23

    Su

  • TYS–ECP, 08/24/26 – 08/31/26: From $358
    24

    Mo

  • TYS–ECP, 08/25/26 – 09/01/26: From $487
    25

    Tu

  • TYS–ECP, 08/26/26 – 09/02/26: From $358
    26

    We

  • TYS–ECP, 08/27/26 – 09/03/26: From $527
    27

    Th

  • TYS–ECP, 08/28/26 – 09/04/26: From $408
    28

    Fr

  • TYS–ECP, 08/29/26 – 09/05/26: From $256
    29

    Sa

  • TYS–ECP, 08/30/26 – 09/06/26: From $348
    30

    Su

  • TYS–ECP, 08/31/26 – 09/07/26: From $719
    31

    Mo

  • TYS–ECP, 09/01/26 – 09/08/26: From $269
    01

    Tu

    SEP

  • TYS–ECP, 09/02/26 – 09/09/26: From $398
    02

    We

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    03

    Th

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    05

    Sa

    • range$256-$719

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to Panama City flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    Panama City (ECP)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $256Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/30/26 - 11/06/26

    Round trip

    Economy

    from
    $266Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    09/08/26 - 09/15/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    09/01/26 - 09/08/26

    Round trip

    Economy

    from
    $269Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to Panama City

    Looking for lower fares on your trip from Knoxville to Panama City? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to Panama City