American Airlines flights from Knoxville to Panama City

Recent searches for flights from Knoxville to Panama City

Sep 2026
From$368*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$289*
Updated: 1 hour ago
Round tripIEconomy
Nov 2026
From$289*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $368
cmp-daily-histogram-bars-legend-max-price-aria-label $914
Displaying fares for September-2026
  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    04

    Fr

    SEP

  • TYS–ECP, 09/05/26 – 09/12/26: From $662
    05

    Sa

  • TYS–ECP, 09/06/26 – 09/13/26: From $718
    06

    Su

  • TYS–ECP, 09/07/26 – 09/14/26: From $662
    07

    Mo

  • TYS–ECP, 09/08/26 – 09/15/26: From $662
    08

    Tu

  • TYS–ECP, 09/09/26 – 09/16/26: From $662
    09

    We

  • TYS–ECP, 09/10/26 – 09/17/26: From $858
    10

    Th

  • TYS–ECP, 09/11/26 – 09/18/26: From $748
    11

    Fr

  • TYS–ECP, 09/12/26 – 09/19/26: From $895
    12

    Sa

  • TYS–ECP, 09/13/26 – 09/20/26: From $693
    13

    Su

  • TYS–ECP, 09/14/26 – 09/21/26: From $748
    14

    Mo

  • TYS–ECP, 09/15/26 – 09/22/26: From $577
    15

    Tu

  • TYS–ECP, 09/16/26 – 09/23/26: From $577
    16

    We

  • TYS–ECP, 09/17/26 – 09/24/26: From $748
    17

    Th

  • TYS–ECP, 09/18/26 – 09/25/26: From $695
    18

    Fr

  • TYS–ECP, 09/19/26 – 09/26/26: From $599
    19

    Sa

  • TYS–ECP, 09/20/26 – 09/27/26: From $673
    20

    Su

  • TYS–ECP, 09/21/26 – 09/28/26: From $637
    21

    Mo

  • TYS–ECP, 09/22/26 – 09/29/26: From $368
    22

    Tu

  • TYS–ECP, 09/23/26 – 09/30/26: From $617
    23

    We

  • TYS–ECP, 09/24/26 – 10/01/26: From $858
    24

    Th

  • TYS–ECP, 09/25/26 – 10/02/26: From $596
    25

    Fr

  • TYS–ECP, 09/26/26 – 10/03/26: From $637
    26

    Sa

  • TYS–ECP, 09/27/26 – 10/04/26: From $804
    27

    Su

  • TYS–ECP, 09/28/26 – 10/05/26: From $408
    28

    Mo

  • TYS–ECP, 09/29/26 – 10/06/26: From $408
    29

    Tu

  • TYS–ECP, 09/30/26 – 10/07/26: From $617
    30

    We

  • TYS–ECP, 10/01/26 – 10/08/26: From $914
    01

    Th

    OCT

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    02

    Fr

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    03

    Sa

    • range$368-$914

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to Panama City flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    Panama City (ECP)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    11/09/26 - 11/16/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    Knoxville (TYS)to

    Panama City (ECP)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $289Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to Panama City

    Looking for lower fares on your trip from Knoxville to Panama City? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Knoxville to Panama City