American Airlines flights from Knoxville to San Diego

Recent searches for flights from Knoxville to San Diego

Sep 2026
From$528*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$411*
Updated: 3 hours ago
Round tripIEconomy
Nov 2026
From$411*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $433
cmp-daily-histogram-bars-legend-max-price-aria-label $1.1K
Displaying fares for September-2026
  • TYS–SAN, 09/14/26 – 09/21/26: From $761
    14

    Mo

    SEP

  • TYS–SAN, 09/15/26 – 09/22/26: From $601
    15

    Tu

  • TYS–SAN, 09/16/26 – 09/23/26: From $601
    16

    We

  • TYS–SAN, 09/17/26 – 09/24/26: From $835
    17

    Th

  • TYS–SAN, 09/18/26 – 09/25/26: From $761
    18

    Fr

  • TYS–SAN, 09/19/26 – 09/26/26: From $601
    19

    Sa

  • TYS–SAN, 09/20/26 – 09/27/26: From $832
    20

    Su

  • TYS–SAN, 09/21/26 – 09/28/26: From $684
    21

    Mo

  • TYS–SAN, 09/22/26 – 09/29/26: From $601
    22

    Tu

  • TYS–SAN, 09/23/26 – 09/30/26: From $601
    23

    We

  • TYS–SAN, 09/24/26 – 10/01/26: From $684
    24

    Th

  • TYS–SAN, 09/25/26 – 10/02/26: From $684
    25

    Fr

  • TYS–SAN, 09/26/26 – 10/03/26: From $601
    26

    Sa

  • TYS–SAN, 09/27/26 – 10/04/26: From $1,050
    27

    Su

  • TYS–SAN, 09/28/26 – 10/05/26: From $531
    28

    Mo

  • TYS–SAN, 09/29/26 – 10/06/26: From $528
    29

    Tu

  • TYS–SAN, 09/30/26 – 10/07/26: From $564
    30

    We

  • TYS–SAN, 10/01/26 – 10/08/26: From $761
    01

    Th

    OCT

  • TYS–SAN, 10/02/26 – 10/09/26: From $782
    02

    Fr

  • TYS–SAN, 10/03/26 – 10/10/26: From $730
    03

    Sa

  • TYS–SAN, 10/04/26 – 10/11/26: From $905
    04

    Su

  • TYS–SAN, 10/05/26 – 10/12/26: From $455
    05

    Mo

  • TYS–SAN, 10/06/26 – 10/13/26: From $433
    06

    Tu

  • TYS–SAN, 10/07/26 – 10/14/26: From $475
    07

    We

  • TYS–SAN, 10/08/26 – 10/15/26: From $581
    08

    Th

  • TYS–SAN, 10/09/26 – 10/16/26: From $455
    09

    Fr

  • TYS–SAN, 10/10/26 – 10/17/26: From $433
    10

    Sa

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    11

    Su

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    13

    Tu

    • range$433-$1,050

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Knoxville to San Diego flights

    $
    keyboard_arrow_down

    Knoxville (TYS)to

    San Diego (SAN)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    Knoxville (TYS)to

    San Diego (SAN)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $411Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Knoxville to San Diego

    Looking for lower fares on your trip from Knoxville to San Diego? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Knoxville to San Diego