American Airlines flights from Minneapolis to San Diego

Recent searches for flights from Minneapolis to San Diego

Sep 2026
From$343*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$343*
Updated: 3 hours ago
Round tripIEconomy
Nov 2026
From$343*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $343
cmp-daily-histogram-bars-legend-max-price-aria-label $779
Displaying fares for September-2026
  • MSP–SAN, 09/02/26 – 09/09/26: From $779
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    SEP

  • MSP–SAN, 09/03/26 – 09/10/26: From $779
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  • MSP–SAN, 09/04/26 – 09/11/26: From $779
    04

    Fr

  • MSP–SAN, 09/05/26 – 09/12/26: From $779
    05

    Sa

  • MSP–SAN, 09/06/26 – 09/13/26: From $779
    06

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  • MSP–SAN, 09/07/26 – 09/14/26: From $779
    07

    Mo

  • MSP–SAN, 09/08/26 – 09/15/26: From $649
    08

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  • MSP–SAN, 09/09/26 – 09/16/26: From $649
    09

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  • MSP–SAN, 09/10/26 – 09/17/26: From $649
    10

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  • MSP–SAN, 09/11/26 – 09/18/26: From $649
    11

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  • MSP–SAN, 09/12/26 – 09/19/26: From $649
    12

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  • MSP–SAN, 09/13/26 – 09/20/26: From $734
    13

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  • MSP–SAN, 09/14/26 – 09/21/26: From $649
    14

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  • MSP–SAN, 09/15/26 – 09/22/26: From $446
    15

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  • MSP–SAN, 09/16/26 – 09/23/26: From $446
    16

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  • MSP–SAN, 09/17/26 – 09/24/26: From $724
    17

    Th

  • MSP–SAN, 09/18/26 – 09/25/26: From $506
    18

    Fr

  • MSP–SAN, 09/19/26 – 09/26/26: From $476
    19

    Sa

  • MSP–SAN, 09/20/26 – 09/27/26: From $519
    20

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  • MSP–SAN, 09/21/26 – 09/28/26: From $476
    21

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  • MSP–SAN, 09/22/26 – 09/29/26: From $343
    22

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  • MSP–SAN, 09/23/26 – 09/30/26: From $343
    23

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  • MSP–SAN, 09/24/26 – 10/01/26: From $527
    24

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  • MSP–SAN, 09/25/26 – 10/02/26: From $410
    25

    Fr

  • MSP–SAN, 09/26/26 – 10/03/26: From $343
    26

    Sa

  • MSP–SAN, 09/27/26 – 10/04/26: From $434
    27

    Su

  • MSP–SAN, 09/28/26 – 10/05/26: From $381
    28

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  • MSP–SAN: cmp-view-offers-disclaimer. Find Offers
    29

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  • MSP–SAN, 09/30/26 – 10/04/26: From $361
    30

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  • MSP–SAN: cmp-view-offers-disclaimer. Find Offers
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    OCT

    • range$343-$779

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Minneapolis to San Diego flights

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    Minneapolis (MSP)to

    San Diego (SAN)
    09/22/26 - 09/29/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    Minneapolis (MSP)to

    San Diego (SAN)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $343Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Minneapolis to San Diego

    Looking for lower fares on your trip from Minneapolis to San Diego? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Minneapolis to San Diego