American Airlines flights from Greenville to San Diego

Recent searches for flights from Greenville to San Diego

Aug 2026
From$581*
Updated: 7 hours ago
Round tripIEconomy
Sep 2026
From$299*
Updated: 7 hours ago
Round tripIEconomy
Oct 2026
From$299*
Updated: 20 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $299
cmp-daily-histogram-bars-legend-max-price-aria-label $819
Displaying fares for August-2026
  • GSP–SAN, 08/25/26 – 09/01/26: From $581
    25

    Tu

    AUG

  • GSP–SAN, 08/26/26 – 09/02/26: From $581
    26

    We

  • GSP–SAN, 08/27/26 – 09/03/26: From $741
    27

    Th

  • GSP–SAN, 08/28/26 – 09/04/26: From $741
    28

    Fr

  • GSP–SAN, 08/29/26 – 09/05/26: From $581
    29

    Sa

  • GSP–SAN, 08/30/26 – 09/06/26: From $741
    30

    Su

  • GSP–SAN, 08/31/26 – 09/07/26: From $787
    31

    Mo

  • GSP–SAN, 09/01/26 – 09/08/26: From $581
    01

    Tu

    SEP

  • GSP–SAN, 09/02/26 – 09/09/26: From $581
    02

    We

  • GSP–SAN, 09/03/26 – 09/10/26: From $669
    03

    Th

  • GSP–SAN, 09/04/26 – 09/11/26: From $787
    04

    Fr

  • GSP–SAN, 09/05/26 – 09/12/26: From $674
    05

    Sa

  • GSP–SAN, 09/06/26 – 09/13/26: From $622
    06

    Su

  • GSP–SAN, 09/07/26 – 09/14/26: From $448
    07

    Mo

  • GSP–SAN, 09/08/26 – 09/15/26: From $440
    08

    Tu

  • GSP–SAN, 09/09/26 – 09/16/26: From $355
    09

    We

  • GSP–SAN, 09/10/26 – 09/17/26: From $530
    10

    Th

  • GSP–SAN, 09/11/26 – 09/18/26: From $819
    11

    Fr

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Sa

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    13

    Su

  • GSP–SAN, 09/14/26 – 09/21/26: From $673
    14

    Mo

  • GSP–SAN, 09/15/26 – 09/22/26: From $299
    15

    Tu

  • GSP–SAN, 09/16/26 – 09/23/26: From $350
    16

    We

  • GSP–SAN, 09/17/26 – 09/24/26: From $460
    17

    Th

  • GSP–SAN, 09/18/26 – 09/25/26: From $422
    18

    Fr

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    19

    Sa

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    20

    Su

  • GSP–SAN, 09/21/26 – 09/28/26: From $474
    21

    Mo

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    22

    Tu

  • GSP–SAN: cmp-view-offers-disclaimer. Find Offers
    23

    We

  • GSP–SAN, 09/24/26 – 10/01/26: From $457
    24

    Th

    • range$299-$819

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Greenville to San Diego flights

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    keyboard_arrow_down

    Greenville (GSP)to

    San Diego (SAN)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    11/02/26 - 11/09/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 20 hours ago

    Greenville (GSP)to

    San Diego (SAN)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $299Fare subject to changes
    Updated: 7 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Greenville to San Diego

    Looking for lower fares on your trip from Greenville to San Diego? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Greenville to San Diego