American Airlines flights from Destin to Buffalo

Recent searches for flights from Destin to Buffalo

Sep 2026
From$393*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$279*
Updated: 3 hours ago
Round tripIEconomy
Nov 2026
From$279*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $303
cmp-daily-histogram-bars-legend-max-price-aria-label $896
Displaying fares for September-2026
  • VPS–BUF, 09/11/26 – 09/18/26: From $896
    11

    Fr

    SEP

  • VPS–BUF, 09/12/26 – 09/19/26: From $839
    12

    Sa

  • VPS–BUF, 09/13/26 – 09/20/26: From $799
    13

    Su

  • VPS–BUF, 09/14/26 – 09/21/26: From $793
    14

    Mo

  • VPS–BUF, 09/15/26 – 09/22/26: From $793
    15

    Tu

  • VPS–BUF, 09/16/26 – 09/23/26: From $799
    16

    We

  • VPS–BUF, 09/17/26 – 09/24/26: From $626
    17

    Th

  • VPS–BUF, 09/18/26 – 09/25/26: From $620
    18

    Fr

  • VPS–BUF, 09/19/26 – 09/26/26: From $620
    19

    Sa

  • VPS–BUF, 09/20/26 – 09/27/26: From $620
    20

    Su

  • VPS–BUF, 09/21/26 – 09/28/26: From $734
    21

    Mo

  • VPS–BUF, 09/22/26 – 09/29/26: From $620
    22

    Tu

  • VPS–BUF, 09/23/26 – 09/30/26: From $620
    23

    We

  • VPS–BUF, 09/24/26 – 10/01/26: From $556
    24

    Th

  • VPS–BUF, 09/25/26 – 10/02/26: From $510
    25

    Fr

  • VPS–BUF, 09/26/26 – 10/03/26: From $393
    26

    Sa

  • VPS–BUF, 09/27/26 – 10/04/26: From $582
    27

    Su

  • VPS–BUF, 09/28/26 – 10/05/26: From $609
    28

    Mo

  • VPS–BUF, 09/29/26 – 10/06/26: From $411
    29

    Tu

  • VPS–BUF, 09/30/26 – 10/07/26: From $433
    30

    We

  • VPS–BUF, 10/01/26 – 10/08/26: From $572
    01

    Th

    OCT

  • VPS–BUF, 10/02/26 – 10/09/26: From $656
    02

    Fr

  • VPS–BUF, 10/03/26 – 10/10/26: From $582
    03

    Sa

  • VPS–BUF, 10/04/26 – 10/11/26: From $671
    04

    Su

  • VPS–BUF, 10/05/26 – 10/12/26: From $435
    05

    Mo

  • VPS–BUF, 10/06/26 – 10/13/26: From $325
    06

    Tu

  • VPS–BUF, 10/07/26 – 10/14/26: From $303
    07

    We

  • VPS–BUF: cmp-view-offers-disclaimer. Find Offers
    08

    Th

  • VPS–BUF: cmp-view-offers-disclaimer. Find Offers
    09

    Fr

  • VPS–BUF: cmp-view-offers-disclaimer. Find Offers
    10

    Sa

    • range$303-$896

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Destin to Buffalo flights

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    keyboard_arrow_down

    Destin (VPS)to

    Buffalo (BUF)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    12/06/26 - 12/13/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    Destin (VPS)to

    Buffalo (BUF)
    11/25/26 - 12/02/26

    Round trip

    Economy

    from
    $279Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Destin to Buffalo

    Looking for lower fares on your trip from Destin to Buffalo? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Destin to Buffalo