American Airlines flights from Charleston, SC to Key West

Recent searches for flights from Charleston, SC to Key West

Sep 2026
From$465*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$361*
Updated: 10 hours ago
Round tripIEconomy
Nov 2026
From$361*
Updated: 10 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $413
cmp-daily-histogram-bars-legend-max-price-aria-label $703
Displaying fares for September-2026
  • CHS–EYW: cmp-view-offers-disclaimer. Find Offers
    14

    Mo

    SEP

  • CHS–EYW, 09/15/26 – 09/22/26: From $465
    15

    Tu

  • CHS–EYW, 09/16/26 – 09/23/26: From $465
    16

    We

  • CHS–EYW, 09/17/26 – 09/24/26: From $623
    17

    Th

  • CHS–EYW, 09/18/26 – 09/25/26: From $623
    18

    Fr

  • CHS–EYW, 09/19/26 – 09/26/26: From $489
    19

    Sa

  • CHS–EYW, 09/20/26 – 09/27/26: From $703
    20

    Su

  • CHS–EYW, 09/21/26 – 09/28/26: From $601
    21

    Mo

  • CHS–EYW, 09/22/26 – 09/29/26: From $465
    22

    Tu

  • CHS–EYW, 09/23/26 – 09/30/26: From $489
    23

    We

  • CHS–EYW, 09/24/26 – 10/01/26: From $601
    24

    Th

  • CHS–EYW, 09/25/26 – 10/02/26: From $601
    25

    Fr

  • CHS–EYW, 09/26/26 – 10/03/26: From $465
    26

    Sa

  • CHS–EYW, 09/27/26 – 10/04/26: From $497
    27

    Su

  • CHS–EYW, 09/28/26 – 10/05/26: From $497
    28

    Mo

  • CHS–EYW, 09/29/26 – 10/06/26: From $465
    29

    Tu

  • CHS–EYW, 09/30/26 – 10/07/26: From $465
    30

    We

  • CHS–EYW, 10/01/26 – 10/08/26: From $497
    01

    Th

    OCT

  • CHS–EYW, 10/02/26 – 10/09/26: From $497
    02

    Fr

  • CHS–EYW, 10/03/26 – 10/10/26: From $465
    03

    Sa

  • CHS–EYW, 10/04/26 – 10/11/26: From $614
    04

    Su

  • CHS–EYW, 10/05/26 – 10/12/26: From $614
    05

    Mo

  • CHS–EYW, 10/06/26 – 10/13/26: From $451
    06

    Tu

  • CHS–EYW, 10/07/26 – 10/14/26: From $413
    07

    We

  • CHS–EYW, 10/08/26 – 10/15/26: From $660
    08

    Th

  • CHS–EYW, 10/09/26 – 10/16/26: From $604
    09

    Fr

  • CHS–EYW, 10/10/26 – 10/17/26: From $561
    10

    Sa

  • CHS–EYW, 10/11/26 – 10/18/26: From $590
    11

    Su

  • CHS–EYW: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • CHS–EYW: cmp-view-offers-disclaimer. Find Offers
    13

    Tu

    • range$413-$703

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Charleston, SC to Key West flights

    $
    keyboard_arrow_down

    Charleston, SC (CHS)to

    Key West (EYW)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    12/09/26 - 12/16/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    11/14/26 - 11/21/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    11/24/26 - 12/01/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    11/25/26 - 12/02/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    Charleston, SC (CHS)to

    Key West (EYW)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $361Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Charleston, SC to Key West

    Looking for lower fares on your trip from Charleston, SC to Key West? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Charleston, SC to Key West