American Airlines flights from Charlotte to Des Moines

Recent searches for flights from Charlotte to Des Moines

Aug 2026
From$455*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$401*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$401*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $401
cmp-daily-histogram-bars-legend-max-price-aria-label $735
Displaying fares for August-2026
  • CLT–DSM, 08/24/26 – 08/28/26: From $735
    24

    Mo

    AUG

  • CLT–DSM, 08/25/26 – 09/01/26: From $455
    25

    Tu

  • CLT–DSM, 08/26/26 – 09/02/26: From $455
    26

    We

  • CLT–DSM, 08/27/26 – 09/03/26: From $565
    27

    Th

  • CLT–DSM, 08/28/26 – 09/04/26: From $525
    28

    Fr

  • CLT–DSM, 08/29/26 – 09/05/26: From $455
    29

    Sa

  • CLT–DSM, 08/30/26 – 09/06/26: From $525
    30

    Su

  • CLT–DSM, 08/31/26 – 09/07/26: From $525
    31

    Mo

  • CLT–DSM, 09/01/26 – 09/08/26: From $455
    01

    Tu

    SEP

  • CLT–DSM, 09/02/26 – 09/09/26: From $455
    02

    We

  • CLT–DSM, 09/03/26 – 09/10/26: From $525
    03

    Th

  • CLT–DSM, 09/04/26 – 09/08/26: From $490
    04

    Fr

  • CLT–DSM, 09/05/26 – 09/12/26: From $428
    05

    Sa

  • CLT–DSM, 09/06/26 – 09/13/26: From $463
    06

    Su

  • CLT–DSM, 09/07/26 – 09/14/26: From $514
    07

    Mo

  • CLT–DSM, 09/08/26 – 09/15/26: From $455
    08

    Tu

  • CLT–DSM, 09/09/26 – 09/12/26: From $401
    09

    We

  • CLT–DSM, 09/10/26 – 09/17/26: From $452
    10

    Th

  • CLT–DSM, 09/11/26 – 09/18/26: From $463
    11

    Fr

  • CLT–DSM, 09/12/26 – 09/19/26: From $428
    12

    Sa

  • CLT–DSM, 09/13/26 – 09/20/26: From $525
    13

    Su

  • CLT–DSM, 09/14/26 – 09/21/26: From $524
    14

    Mo

  • CLT–DSM, 09/15/26 – 09/22/26: From $455
    15

    Tu

  • CLT–DSM, 09/16/26 – 09/23/26: From $428
    16

    We

  • CLT–DSM, 09/17/26 – 09/24/26: From $492
    17

    Th

  • CLT–DSM, 09/18/26 – 09/25/26: From $503
    18

    Fr

  • CLT–DSM, 09/19/26 – 09/26/26: From $428
    19

    Sa

  • CLT–DSM, 09/20/26 – 09/27/26: From $503
    20

    Su

  • CLT–DSM, 09/21/26 – 09/24/26: From $503
    21

    Mo

  • CLT–DSM: cmp-view-offers-disclaimer. Find Offers
    22

    Tu

  • CLT–DSM, 09/23/26 – 09/28/26: From $441
    23

    We

    • range$401-$735

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Charlotte to Des Moines flights

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    Charlotte (CLT)to

    Des Moines (DSM)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    09/29/26 - 10/06/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    Charlotte (CLT)to

    Des Moines (DSM)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $401Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Charlotte to Des Moines

    Looking for lower fares on your trip from Charlotte to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Charlotte to Des Moines