American Airlines flights from Chicago to Des Moines

Recent searches for flights from Chicago to Des Moines

Aug 2026
From$249*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$249*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$261*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $249
cmp-daily-histogram-bars-legend-max-price-aria-label $1.2K
Displaying fares for August-2026
  • ORD–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Tu

    AUG

  • ORD–DSM, 08/05/26 – 08/12/26: From $1,239
    05

    We

  • ORD–DSM, 08/06/26 – 08/13/26: From $751
    06

    Th

  • ORD–DSM, 08/07/26 – 08/14/26: From $674
    07

    Fr

  • ORD–DSM, 08/08/26 – 08/15/26: From $614
    08

    Sa

  • ORD–DSM, 08/09/26 – 08/16/26: From $674
    09

    Su

  • ORD–DSM, 08/10/26 – 08/17/26: From $674
    10

    Mo

  • ORD–DSM, 08/11/26 – 08/18/26: From $564
    11

    Tu

  • ORD–DSM, 08/12/26 – 08/19/26: From $564
    12

    We

  • ORD–DSM, 08/13/26 – 08/20/26: From $624
    13

    Th

  • ORD–DSM, 08/14/26 – 08/21/26: From $477
    14

    Fr

  • ORD–DSM, 08/15/26 – 08/22/26: From $477
    15

    Sa

  • ORD–DSM, 08/16/26 – 08/23/26: From $477
    16

    Su

  • ORD–DSM, 08/17/26 – 08/24/26: From $477
    17

    Mo

  • ORD–DSM, 08/18/26 – 08/25/26: From $344
    18

    Tu

  • ORD–DSM, 08/19/26 – 08/26/26: From $344
    19

    We

  • ORD–DSM, 08/20/26 – 08/27/26: From $344
    20

    Th

  • ORD–DSM, 08/21/26 – 08/28/26: From $364
    21

    Fr

  • ORD–DSM, 08/22/26 – 08/29/26: From $344
    22

    Sa

  • ORD–DSM, 08/23/26 – 08/30/26: From $397
    23

    Su

  • ORD–DSM, 08/24/26 – 08/31/26: From $344
    24

    Mo

  • ORD–DSM, 08/25/26 – 09/01/26: From $261
    25

    Tu

  • ORD–DSM, 08/26/26 – 09/02/26: From $261
    26

    We

  • ORD–DSM, 08/27/26 – 09/03/26: From $261
    27

    Th

  • ORD–DSM, 08/28/26 – 09/04/26: From $301
    28

    Fr

  • ORD–DSM, 08/29/26 – 09/05/26: From $249
    29

    Sa

  • ORD–DSM, 08/30/26 – 09/06/26: From $302
    30

    Su

  • ORD–DSM, 08/31/26 – 09/07/26: From $261
    31

    Mo

  • ORD–DSM, 09/01/26 – 09/03/26: From $261
    01

    Tu

    SEP

  • ORD–DSM: cmp-view-offers-disclaimer. Find Offers
    02

    We

  • ORD–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Th

    • range$249-$1,239

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Chicago to Des Moines flights

    $
    keyboard_arrow_down

    Chicago (ORD)to

    Des Moines (DSM)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $249Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $249Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    09/10/26 - 09/17/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    Chicago (ORD)to

    Des Moines (DSM)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $261Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Chicago to Des Moines

    Looking for lower fares on your trip from Chicago to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Chicago to Des Moines