American Airlines flights from Chicago to Des Moines

Recent searches for flights from Chicago to Des Moines

Sep 2026
From$353*
Updated: 28 minutes ago
Round tripIEconomy
Oct 2026
From$239*
Updated: 28 minutes ago
Round tripIEconomy
Nov 2026
From$239*
Updated: 28 minutes ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $239
cmp-daily-histogram-bars-legend-max-price-aria-label $567
Displaying fares for September-2026
  • ORD–DSM, 09/14/26 – 09/21/26: From $567
    14

    Mo

    SEP

  • ORD–DSM, 09/15/26 – 09/22/26: From $567
    15

    Tu

  • ORD–DSM, 09/16/26 – 09/23/26: From $567
    16

    We

  • ORD–DSM, 09/17/26 – 09/24/26: From $567
    17

    Th

  • ORD–DSM, 09/18/26 – 09/25/26: From $567
    18

    Fr

  • ORD–DSM, 09/19/26 – 09/26/26: From $567
    19

    Sa

  • ORD–DSM, 09/20/26 – 09/27/26: From $567
    20

    Su

  • ORD–DSM, 09/21/26 – 09/28/26: From $517
    21

    Mo

  • ORD–DSM, 09/22/26 – 09/29/26: From $517
    22

    Tu

  • ORD–DSM, 09/23/26 – 09/30/26: From $517
    23

    We

  • ORD–DSM, 09/24/26 – 10/01/26: From $517
    24

    Th

  • ORD–DSM, 09/25/26 – 10/02/26: From $517
    25

    Fr

  • ORD–DSM, 09/26/26 – 10/03/26: From $517
    26

    Sa

  • ORD–DSM, 09/27/26 – 10/04/26: From $517
    27

    Su

  • ORD–DSM, 09/28/26 – 10/05/26: From $370
    28

    Mo

  • ORD–DSM, 09/29/26 – 10/06/26: From $353
    29

    Tu

  • ORD–DSM, 09/30/26 – 10/07/26: From $353
    30

    We

  • ORD–DSM, 10/01/26 – 10/08/26: From $370
    01

    Th

    OCT

  • ORD–DSM, 10/02/26 – 10/09/26: From $388
    02

    Fr

  • ORD–DSM, 10/03/26 – 10/10/26: From $353
    03

    Sa

  • ORD–DSM, 10/04/26 – 10/11/26: From $437
    04

    Su

  • ORD–DSM, 10/05/26 – 10/12/26: From $273
    05

    Mo

  • ORD–DSM, 10/06/26 – 10/13/26: From $239
    06

    Tu

  • ORD–DSM, 10/07/26 – 10/14/26: From $239
    07

    We

  • ORD–DSM, 10/08/26 – 10/15/26: From $273
    08

    Th

  • ORD–DSM, 10/09/26 – 10/16/26: From $309
    09

    Fr

  • ORD–DSM, 10/10/26 – 10/17/26: From $239
    10

    Sa

  • ORD–DSM, 10/11/26 – 10/18/26: From $393
    11

    Su

  • ORD–DSM: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • ORD–DSM: cmp-view-offers-disclaimer. Find Offers
    13

    Tu

    • range$239-$567

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Chicago to Des Moines flights

    $
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    Chicago (ORD)to

    Des Moines (DSM)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    Chicago (ORD)to

    Des Moines (DSM)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $239Fare subject to changes
    Updated: 28 minutes ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Chicago to Des Moines

    Looking for lower fares on your trip from Chicago to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Chicago to Des Moines