American Airlines flights from Destin to Des Moines

Recent searches for flights from Destin to Des Moines

Sep 2026
From$409*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$323*
Updated: 9 hours ago
Round tripIEconomy
Nov 2026
From$323*
Updated: 9 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $323
cmp-daily-histogram-bars-legend-max-price-aria-label $795
Displaying fares for September-2026
  • VPS–DSM: cmp-view-offers-disclaimer. Find Offers
    10

    Th

    SEP

  • VPS–DSM, 09/11/26 – 09/18/26: From $695
    11

    Fr

  • VPS–DSM, 09/12/26 – 09/19/26: From $533
    12

    Sa

  • VPS–DSM, 09/13/26 – 09/20/26: From $741
    13

    Su

  • VPS–DSM, 09/14/26 – 09/21/26: From $795
    14

    Mo

  • VPS–DSM, 09/15/26 – 09/22/26: From $533
    15

    Tu

  • VPS–DSM, 09/16/26 – 09/23/26: From $533
    16

    We

  • VPS–DSM, 09/17/26 – 09/24/26: From $695
    17

    Th

  • VPS–DSM, 09/18/26 – 09/25/26: From $701
    18

    Fr

  • VPS–DSM, 09/19/26 – 09/26/26: From $539
    19

    Sa

  • VPS–DSM, 09/20/26 – 09/27/26: From $631
    20

    Su

  • VPS–DSM, 09/21/26 – 09/28/26: From $631
    21

    Mo

  • VPS–DSM, 09/22/26 – 09/29/26: From $514
    22

    Tu

  • VPS–DSM, 09/23/26 – 09/30/26: From $539
    23

    We

  • VPS–DSM, 09/24/26 – 10/01/26: From $651
    24

    Th

  • VPS–DSM, 09/25/26 – 10/02/26: From $589
    25

    Fr

  • VPS–DSM, 09/26/26 – 10/03/26: From $409
    26

    Sa

  • VPS–DSM, 09/27/26 – 10/04/26: From $681
    27

    Su

  • VPS–DSM, 09/28/26 – 10/05/26: From $555
    28

    Mo

  • VPS–DSM, 09/29/26 – 10/06/26: From $409
    29

    Tu

  • VPS–DSM, 09/30/26 – 10/07/26: From $481
    30

    We

  • VPS–DSM, 10/01/26 – 10/08/26: From $777
    01

    Th

    OCT

  • VPS–DSM, 10/02/26 – 10/09/26: From $552
    02

    Fr

  • VPS–DSM, 10/03/26 – 10/10/26: From $346
    03

    Sa

  • VPS–DSM, 10/04/26 – 10/11/26: From $656
    04

    Su

  • VPS–DSM, 10/05/26 – 10/12/26: From $346
    05

    Mo

  • VPS–DSM, 10/06/26 – 10/13/26: From $323
    06

    Tu

  • VPS–DSM, 10/07/26 – 10/14/26: From $351
    07

    We

  • VPS–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Th

  • VPS–DSM: cmp-view-offers-disclaimer. Find Offers
    09

    Fr

    • range$323-$795

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Destin to Des Moines flights

    $
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    Destin (VPS)to

    Des Moines (DSM)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 4 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    11/02/26 - 11/09/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    10/22/26 - 10/29/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    Destin (VPS)to

    Des Moines (DSM)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $323Fare subject to changes
    Updated: 9 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Destin to Des Moines

    Looking for lower fares on your trip from Destin to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Destin to Des Moines