American Airlines flights from Charleston, SC to Des Moines

Recent searches for flights from Charleston, SC to Des Moines

Aug 2026
From$345*
Updated: 2 hours ago
Round tripIEconomy
Sep 2026
From$326*
Updated: 2 hours ago
Round tripIEconomy
Oct 2026
From$358*
Updated: 2 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $345
cmp-daily-histogram-bars-legend-max-price-aria-label $892
Displaying fares for August-2026
  • CHS–DSM, 08/05/26 – 08/12/26: From $773
    05

    We

    AUG

  • CHS–DSM, 08/06/26 – 08/13/26: From $892
    06

    Th

  • CHS–DSM, 08/07/26 – 08/14/26: From $892
    07

    Fr

  • CHS–DSM, 08/08/26 – 08/15/26: From $775
    08

    Sa

  • CHS–DSM, 08/09/26 – 08/16/26: From $892
    09

    Su

  • CHS–DSM, 08/10/26 – 08/17/26: From $892
    10

    Mo

  • CHS–DSM, 08/11/26 – 08/18/26: From $769
    11

    Tu

  • CHS–DSM, 08/12/26 – 08/19/26: From $673
    12

    We

  • CHS–DSM, 08/13/26 – 08/20/26: From $673
    13

    Th

  • CHS–DSM, 08/14/26 – 08/21/26: From $673
    14

    Fr

  • CHS–DSM, 08/15/26 – 08/22/26: From $673
    15

    Sa

  • CHS–DSM, 08/16/26 – 08/23/26: From $673
    16

    Su

  • CHS–DSM, 08/17/26 – 08/24/26: From $673
    17

    Mo

  • CHS–DSM, 08/18/26 – 08/25/26: From $672
    18

    Tu

  • CHS–DSM, 08/19/26 – 08/26/26: From $431
    19

    We

  • CHS–DSM, 08/20/26 – 08/27/26: From $431
    20

    Th

  • CHS–DSM, 08/21/26 – 08/28/26: From $444
    21

    Fr

  • CHS–DSM, 08/22/26 – 08/29/26: From $431
    22

    Sa

  • CHS–DSM, 08/23/26 – 08/30/26: From $467
    23

    Su

  • CHS–DSM, 08/24/26 – 08/31/26: From $431
    24

    Mo

  • CHS–DSM, 08/25/26 – 09/01/26: From $431
    25

    Tu

  • CHS–DSM, 08/26/26 – 09/02/26: From $365
    26

    We

  • CHS–DSM, 08/27/26 – 09/03/26: From $365
    27

    Th

  • CHS–DSM, 08/28/26 – 09/04/26: From $391
    28

    Fr

  • CHS–DSM, 08/29/26 – 09/05/26: From $345
    29

    Sa

  • CHS–DSM, 08/30/26 – 09/06/26: From $381
    30

    Su

  • CHS–DSM, 08/31/26 – 09/07/26: From $365
    31

    Mo

  • CHS–DSM, 09/01/26 – 09/08/26: From $365
    01

    Tu

    SEP

  • CHS–DSM: cmp-view-offers-disclaimer. Find Offers
    02

    We

  • CHS–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Th

  • CHS–DSM, 09/04/26 – 09/11/26: From $358
    04

    Fr

    • range$345-$892

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Charleston, SC to Des Moines flights

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    Charleston, SC (CHS)to

    Des Moines (DSM)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $326Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    08/29/26 - 09/05/26

    Round trip

    Economy

    from
    $345Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $346Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    09/10/26 - 09/17/26

    Round trip

    Economy

    from
    $346Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    09/12/26 - 09/19/26

    Round trip

    Economy

    from
    $346Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $358Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    10/30/26 - 11/06/26

    Round trip

    Economy

    from
    $358Fare subject to changes
    Updated: 2 hours ago

    Charleston, SC (CHS)to

    Des Moines (DSM)
    09/11/26 - 09/18/26

    Round trip

    Economy

    from
    $358Fare subject to changes
    Updated: 2 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Charleston, SC to Des Moines

    Looking for lower fares on your trip from Charleston, SC to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Charleston, SC to Des Moines