American Airlines flights from Houston to Des Moines

Recent searches for flights from Houston to Des Moines

Sep 2026
From$359*
Updated: 6 hours ago
Round tripIEconomy
Oct 2026
From$339*
Updated: 6 hours ago
Round tripIEconomy
Nov 2026
From$339*
Updated: 6 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $339
cmp-daily-histogram-bars-legend-max-price-aria-label $509
Displaying fares for September-2026
  • IAH–DSM: cmp-view-offers-disclaimer. Find Offers
    14

    Mo

    SEP

  • IAH–DSM, 09/15/26 – 09/22/26: From $509
    15

    Tu

  • IAH–DSM, 09/16/26 – 09/23/26: From $509
    16

    We

  • IAH–DSM, 09/17/26 – 09/24/26: From $509
    17

    Th

  • IAH–DSM, 09/18/26 – 09/25/26: From $509
    18

    Fr

  • IAH–DSM, 09/19/26 – 09/26/26: From $509
    19

    Sa

  • IAH–DSM, 09/20/26 – 09/27/26: From $509
    20

    Su

  • IAH–DSM, 09/21/26 – 09/28/26: From $414
    21

    Mo

  • IAH–DSM, 09/22/26 – 09/29/26: From $414
    22

    Tu

  • IAH–DSM, 09/23/26 – 09/30/26: From $414
    23

    We

  • IAH–DSM, 09/24/26 – 10/01/26: From $414
    24

    Th

  • IAH–DSM, 09/25/26 – 10/02/26: From $414
    25

    Fr

  • IAH–DSM, 09/26/26 – 10/03/26: From $414
    26

    Sa

  • IAH–DSM, 09/27/26 – 10/04/26: From $414
    27

    Su

  • IAH–DSM, 09/28/26 – 10/05/26: From $359
    28

    Mo

  • IAH–DSM, 09/29/26 – 10/06/26: From $359
    29

    Tu

  • IAH–DSM, 09/30/26 – 10/07/26: From $359
    30

    We

  • IAH–DSM, 10/01/26 – 10/08/26: From $359
    01

    Th

    OCT

  • IAH–DSM, 10/02/26 – 10/09/26: From $359
    02

    Fr

  • IAH–DSM, 10/03/26 – 10/10/26: From $359
    03

    Sa

  • IAH–DSM, 10/04/26 – 10/11/26: From $359
    04

    Su

  • IAH–DSM, 10/05/26 – 10/12/26: From $339
    05

    Mo

  • IAH–DSM, 10/06/26 – 10/13/26: From $339
    06

    Tu

  • IAH–DSM, 10/07/26 – 10/14/26: From $339
    07

    We

  • IAH–DSM, 10/08/26 – 10/15/26: From $339
    08

    Th

  • IAH–DSM, 10/09/26 – 10/16/26: From $339
    09

    Fr

  • IAH–DSM, 10/10/26 – 10/17/26: From $339
    10

    Sa

  • IAH–DSM, 10/11/26 – 10/18/26: From $419
    11

    Su

  • IAH–DSM: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • IAH–DSM: cmp-view-offers-disclaimer. Find Offers
    13

    Tu

    • range$339-$509

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Houston to Des Moines flights

    $
    keyboard_arrow_down

    Houston (IAH)to

    Des Moines (DSM)
    10/05/26 - 10/12/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/22/26 - 10/29/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/26/26 - 11/02/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    Houston (IAH)to

    Des Moines (DSM)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 6 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Houston to Des Moines

    Looking for lower fares on your trip from Houston to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Houston to Des Moines