American Airlines flights from Mcallen to Des Moines

Recent searches for flights from Mcallen to Des Moines

Aug 2026
From$355*
Updated: 22 hours ago
Round tripIEconomy
Sep 2026
From$295*
Updated: 2 hours ago
Round tripIEconomy
Oct 2026
From$295*
Updated: 2 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $312
cmp-daily-histogram-bars-legend-max-price-aria-label $789
Displaying fares for August-2026
  • MFE–DSM, 08/29/26 – 09/05/26: From $355
    29

    Sa

    AUG

  • MFE–DSM, 08/30/26 – 09/06/26: From $476
    30

    Su

  • MFE–DSM, 08/31/26 – 09/07/26: From $765
    31

    Mo

  • MFE–DSM, 09/01/26 – 09/08/26: From $355
    01

    Tu

    SEP

  • MFE–DSM, 09/02/26 – 09/09/26: From $355
    02

    We

  • MFE–DSM, 09/03/26 – 09/10/26: From $603
    03

    Th

  • MFE–DSM, 09/04/26 – 09/11/26: From $608
    04

    Fr

  • MFE–DSM, 09/05/26 – 09/12/26: From $325
    05

    Sa

  • MFE–DSM, 09/06/26 – 09/13/26: From $517
    06

    Su

  • MFE–DSM, 09/07/26 – 09/14/26: From $789
    07

    Mo

  • MFE–DSM, 09/08/26 – 09/15/26: From $694
    08

    Tu

  • MFE–DSM, 09/09/26 – 09/16/26: From $365
    09

    We

  • MFE–DSM, 09/10/26 – 09/17/26: From $337
    10

    Th

  • MFE–DSM, 09/11/26 – 09/18/26: From $337
    11

    Fr

  • MFE–DSM, 09/12/26 – 09/19/26: From $350
    12

    Sa

  • MFE–DSM, 09/13/26 – 09/20/26: From $518
    13

    Su

  • MFE–DSM, 09/14/26 – 09/21/26: From $460
    14

    Mo

  • MFE–DSM, 09/15/26 – 09/22/26: From $342
    15

    Tu

  • MFE–DSM, 09/16/26 – 09/23/26: From $342
    16

    We

  • MFE–DSM, 09/17/26 – 09/24/26: From $388
    17

    Th

  • MFE–DSM, 09/18/26 – 09/25/26: From $447
    18

    Fr

  • MFE–DSM, 09/19/26 – 09/26/26: From $329
    19

    Sa

  • MFE–DSM, 09/20/26 – 09/27/26: From $471
    20

    Su

  • MFE–DSM, 09/21/26 – 09/28/26: From $388
    21

    Mo

  • MFE–DSM, 09/22/26 – 09/29/26: From $312
    22

    Tu

  • MFE–DSM, 09/23/26 – 09/30/26: From $367
    23

    We

  • MFE–DSM, 09/24/26 – 10/01/26: From $388
    24

    Th

  • MFE–DSM, 09/25/26 – 10/02/26: From $494
    25

    Fr

  • MFE–DSM: cmp-view-offers-disclaimer. Find Offers
    26

    Sa

  • MFE–DSM: cmp-view-offers-disclaimer. Find Offers
    27

    Su

  • MFE–DSM, 09/28/26 – 10/05/26: From $412
    28

    Mo

    • range$312-$789

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Mcallen to Des Moines flights

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    Mcallen (MFE)to

    Des Moines (DSM)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    09/29/26 - 10/06/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    Mcallen (MFE)to

    Des Moines (DSM)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $295Fare subject to changes
    Updated: 2 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Mcallen to Des Moines

    Looking for lower fares on your trip from Mcallen to Des Moines? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Mcallen to Des Moines