American Airlines flights from Detroit to Charleston, SC

Recent searches for flights from Detroit to Charleston, SC

Aug 2026
From$374*
Updated: 8 hours ago
Round tripIEconomy
Sep 2026
From$319*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$369*
Updated: 2 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $369
cmp-daily-histogram-bars-legend-max-price-aria-label $734
Displaying fares for August-2026
  • DTW–CHS, 08/04/26 – 08/11/26: From $734
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  • DTW–CHS, 08/05/26 – 08/12/26: From $734
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  • DTW–CHS, 08/06/26 – 08/13/26: From $734
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  • DTW–CHS, 08/07/26 – 08/14/26: From $734
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  • DTW–CHS, 08/08/26 – 08/15/26: From $734
    08

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  • DTW–CHS, 08/09/26 – 08/16/26: From $734
    09

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  • DTW–CHS, 08/10/26 – 08/17/26: From $614
    10

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  • DTW–CHS, 08/11/26 – 08/18/26: From $614
    11

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  • DTW–CHS, 08/12/26 – 08/19/26: From $614
    12

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  • DTW–CHS, 08/13/26 – 08/20/26: From $614
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  • DTW–CHS, 08/14/26 – 08/21/26: From $614
    14

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  • DTW–CHS, 08/15/26 – 08/22/26: From $614
    15

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  • DTW–CHS, 08/16/26 – 08/23/26: From $614
    16

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  • DTW–CHS, 08/17/26 – 08/24/26: From $479
    17

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  • DTW–CHS, 08/18/26 – 08/25/26: From $479
    18

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  • DTW–CHS, 08/19/26 – 08/26/26: From $479
    19

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  • DTW–CHS, 08/20/26 – 08/27/26: From $479
    20

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  • DTW–CHS, 08/21/26 – 08/28/26: From $479
    21

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  • DTW–CHS, 08/22/26 – 08/29/26: From $472
    22

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  • DTW–CHS, 08/23/26 – 08/30/26: From $479
    23

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  • DTW–CHS, 08/24/26 – 08/31/26: From $411
    24

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  • DTW–CHS, 08/25/26 – 09/01/26: From $411
    25

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  • DTW–CHS, 08/26/26 – 09/02/26: From $374
    26

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  • DTW–CHS, 08/27/26 – 09/03/26: From $399
    27

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  • DTW–CHS, 08/28/26 – 09/04/26: From $399
    28

    Fr

  • DTW–CHS, 08/29/26 – 09/05/26: From $374
    29

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  • DTW–CHS, 08/30/26 – 09/06/26: From $399
    30

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  • DTW–CHS, 08/31/26 – 09/07/26: From $569
    31

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  • DTW–CHS: cmp-view-offers-disclaimer. Find Offers
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  • DTW–CHS: cmp-view-offers-disclaimer. Find Offers
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  • DTW–CHS, 09/03/26 – 09/10/26: From $369
    03

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    • range$369-$734

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Charleston, SC flights

    $
    keyboard_arrow_down

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/19/26 - 09/26/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 2 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/05/26 - 09/12/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/16/26 - 09/23/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    Detroit (DTW)to

    Charleston, SC (CHS)
    09/29/26 - 10/06/26

    Round trip

    Economy

    from
    $319Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Charleston, SC

    Looking for lower fares on your trip from Detroit to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Detroit to Charleston, SC