American Airlines flights from Harrisburg to Charleston, SC

Recent searches for flights from Harrisburg to Charleston, SC

Aug 2026
From$361*
Updated: 4 hours ago
Round tripIEconomy
Sep 2026
From$285*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$285*
Updated: 4 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $302
cmp-daily-histogram-bars-legend-max-price-aria-label $598
Displaying fares for August-2026
  • MDT–CHS, 08/23/26 – 08/30/26: From $424
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  • MDT–CHS, 08/24/26 – 08/31/26: From $424
    24

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  • MDT–CHS, 08/25/26 – 09/01/26: From $361
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  • MDT–CHS, 08/26/26 – 09/02/26: From $361
    26

    We

  • MDT–CHS, 08/27/26 – 09/03/26: From $424
    27

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  • MDT–CHS, 08/28/26 – 09/04/26: From $424
    28

    Fr

  • MDT–CHS, 08/29/26 – 09/05/26: From $361
    29

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  • MDT–CHS, 08/30/26 – 09/06/26: From $379
    30

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  • MDT–CHS, 08/31/26 – 09/07/26: From $598
    31

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  • MDT–CHS, 09/01/26 – 09/08/26: From $355
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    SEP

  • MDT–CHS, 09/02/26 – 09/09/26: From $355
    02

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  • MDT–CHS, 09/03/26 – 09/10/26: From $412
    03

    Th

  • MDT–CHS, 09/04/26 – 09/11/26: From $379
    04

    Fr

  • MDT–CHS, 09/05/26 – 09/12/26: From $317
    05

    Sa

  • MDT–CHS, 09/06/26 – 09/13/26: From $302
    06

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  • MDT–CHS, 09/07/26 – 09/14/26: From $334
    07

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  • MDT–CHS, 09/08/26 – 09/15/26: From $334
    08

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  • MDT–CHS, 09/09/26 – 09/16/26: From $302
    09

    We

  • MDT–CHS, 09/10/26 – 09/17/26: From $347
    10

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  • MDT–CHS, 09/11/26 – 09/18/26: From $347
    11

    Fr

  • MDT–CHS, 09/12/26 – 09/19/26: From $302
    12

    Sa

  • MDT–CHS, 09/13/26 – 09/20/26: From $319
    13

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  • MDT–CHS, 09/14/26 – 09/21/26: From $319
    14

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  • MDT–CHS, 09/15/26 – 09/22/26: From $302
    15

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  • MDT–CHS, 09/16/26 – 09/23/26: From $302
    16

    We

  • MDT–CHS, 09/17/26 – 09/24/26: From $364
    17

    Th

  • MDT–CHS, 09/18/26 – 09/25/26: From $351
    18

    Fr

  • MDT–CHS, 09/19/26 – 09/26/26: From $302
    19

    Sa

  • MDT–CHS: cmp-view-offers-disclaimer. Find Offers
    20

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  • MDT–CHS: cmp-view-offers-disclaimer. Find Offers
    21

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  • MDT–CHS, 09/22/26 – 09/29/26: From $302
    22

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    • range$302-$598

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Harrisburg to Charleston, SC flights

    $
    keyboard_arrow_down

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    09/29/26 - 10/06/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    Harrisburg (MDT)to

    Charleston, SC (CHS)
    09/30/26 - 10/07/26

    Round trip

    Economy

    from
    $285Fare subject to changes
    Updated: 4 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Harrisburg to Charleston, SC

    Looking for lower fares on your trip from Harrisburg to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Harrisburg to Charleston, SC