American Airlines flights from Buffalo to Charleston, SC

Recent searches for flights from Buffalo to Charleston, SC

Sep 2026
From$304*
Updated: 3 hours ago
Round tripIEconomy
Oct 2026
From$177*
Updated: 3 hours ago
Round tripIEconomy
Nov 2026
From$177*
Updated: 3 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $177
cmp-daily-histogram-bars-legend-max-price-aria-label $968
Displaying fares for September-2026
  • BUF–CHS, 09/15/26 – 09/22/26: From $569
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  • BUF–CHS, 09/16/26 – 09/23/26: From $569
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  • BUF–CHS, 09/17/26 – 09/24/26: From $643
    17

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  • BUF–CHS, 09/18/26 – 09/25/26: From $968
    18

    Fr

  • BUF–CHS, 09/19/26 – 09/26/26: From $569
    19

    Sa

  • BUF–CHS, 09/20/26 – 09/27/26: From $643
    20

    Su

  • BUF–CHS, 09/21/26 – 09/28/26: From $507
    21

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  • BUF–CHS, 09/22/26 – 09/29/26: From $458
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  • BUF–CHS, 09/23/26 – 09/30/26: From $458
    23

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  • BUF–CHS, 09/24/26 – 10/01/26: From $507
    24

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  • BUF–CHS, 09/25/26 – 10/02/26: From $573
    25

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  • BUF–CHS, 09/26/26 – 10/03/26: From $458
    26

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  • BUF–CHS, 09/27/26 – 10/04/26: From $573
    27

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  • BUF–CHS, 09/28/26 – 10/05/26: From $380
    28

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  • BUF–CHS, 09/29/26 – 10/06/26: From $304
    29

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  • BUF–CHS, 09/30/26 – 10/07/26: From $304
    30

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  • BUF–CHS, 10/01/26 – 10/08/26: From $343
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    OCT

  • BUF–CHS, 10/02/26 – 10/09/26: From $343
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  • BUF–CHS, 10/03/26 – 10/10/26: From $304
    03

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  • BUF–CHS, 10/04/26 – 10/11/26: From $304
    04

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  • BUF–CHS, 10/05/26 – 10/12/26: From $339
    05

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  • BUF–CHS, 10/06/26 – 10/13/26: From $258
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  • BUF–CHS, 10/07/26 – 10/14/26: From $177
    07

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  • BUF–CHS, 10/08/26 – 10/15/26: From $488
    08

    Th

  • BUF–CHS, 10/09/26 – 10/16/26: From $345
    09

    Fr

  • BUF–CHS, 10/10/26 – 10/17/26: From $177
    10

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  • BUF–CHS, 10/11/26 – 10/18/26: From $261
    11

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  • BUF–CHS: cmp-view-offers-disclaimer. Find Offers
    12

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  • BUF–CHS: cmp-view-offers-disclaimer. Find Offers
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  • BUF–CHS: cmp-view-offers-disclaimer. Find Offers
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    • range$177-$968

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Buffalo to Charleston, SC flights

    $
    keyboard_arrow_down

    Buffalo (BUF)to

    Charleston, SC (CHS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    11/10/26 - 11/17/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    11/18/26 - 11/25/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    Buffalo (BUF)to

    Charleston, SC (CHS)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $177Fare subject to changes
    Updated: 3 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Buffalo to Charleston, SC

    Looking for lower fares on your trip from Buffalo to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
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    American Airlines flights from Buffalo to Charleston, SC