American Airlines flights from Indianapolis to Charleston, SC

Recent searches for flights from Indianapolis to Charleston, SC

Sep 2026
From$445*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$221*
Updated: 8 hours ago
Round tripIEconomy
Nov 2026
From$221*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $221
cmp-daily-histogram-bars-legend-max-price-aria-label $672
Displaying fares for September-2026
  • IND–CHS, 09/15/26 – 09/22/26: From $545
    15

    Tu

    SEP

  • IND–CHS, 09/16/26 – 09/23/26: From $545
    16

    We

  • IND–CHS, 09/17/26 – 09/24/26: From $671
    17

    Th

  • IND–CHS, 09/18/26 – 09/25/26: From $671
    18

    Fr

  • IND–CHS, 09/19/26 – 09/26/26: From $545
    19

    Sa

  • IND–CHS, 09/20/26 – 09/27/26: From $671
    20

    Su

  • IND–CHS, 09/21/26 – 09/28/26: From $624
    21

    Mo

  • IND–CHS, 09/22/26 – 09/29/26: From $521
    22

    Tu

  • IND–CHS, 09/23/26 – 09/30/26: From $521
    23

    We

  • IND–CHS, 09/24/26 – 10/01/26: From $624
    24

    Th

  • IND–CHS, 09/25/26 – 10/02/26: From $624
    25

    Fr

  • IND–CHS, 09/26/26 – 10/03/26: From $521
    26

    Sa

  • IND–CHS, 09/27/26 – 10/04/26: From $624
    27

    Su

  • IND–CHS, 09/28/26 – 10/05/26: From $445
    28

    Mo

  • IND–CHS, 09/29/26 – 10/06/26: From $445
    29

    Tu

  • IND–CHS, 09/30/26 – 10/07/26: From $445
    30

    We

  • IND–CHS, 10/01/26 – 10/08/26: From $564
    01

    Th

    OCT

  • IND–CHS, 10/02/26 – 10/09/26: From $445
    02

    Fr

  • IND–CHS, 10/03/26 – 10/10/26: From $445
    03

    Sa

  • IND–CHS, 10/04/26 – 10/11/26: From $457
    04

    Su

  • IND–CHS, 10/05/26 – 10/12/26: From $249
    05

    Mo

  • IND–CHS, 10/06/26 – 10/13/26: From $221
    06

    Tu

  • IND–CHS, 10/07/26 – 10/14/26: From $221
    07

    We

  • IND–CHS, 10/08/26 – 10/15/26: From $589
    08

    Th

  • IND–CHS, 10/09/26 – 10/16/26: From $672
    09

    Fr

  • IND–CHS, 10/10/26 – 10/17/26: From $386
    10

    Sa

  • IND–CHS, 10/11/26 – 10/18/26: From $594
    11

    Su

  • IND–CHS: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

  • IND–CHS, 10/13/26 – 10/20/26: From $221
    13

    Tu

  • IND–CHS: cmp-view-offers-disclaimer. Find Offers
    14

    We

    • range$221-$672

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Indianapolis to Charleston, SC flights

    $
    keyboard_arrow_down

    Indianapolis (IND)to

    Charleston, SC (CHS)
    11/25/26 - 12/02/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    Indianapolis (IND)to

    Charleston, SC (CHS)
    12/01/26 - 12/08/26

    Round trip

    Economy

    from
    $221Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Indianapolis to Charleston, SC

    Looking for lower fares on your trip from Indianapolis to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
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    American Airlines flights from Indianapolis to Charleston, SC