American Airlines flights from Detroit to Santiago

Recent searches for flights from Detroit to Santiago

Aug 2026
From$1,630*
Updated: 4 hours ago
Round tripIEconomy
Sep 2026
From$1,450*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$1,400*
Updated: 4 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $1.5K
cmp-daily-histogram-bars-legend-max-price-aria-label $1.9K
Displaying fares for August-2026
  • DTW–SCL, 08/16/26 – 08/23/26: From $1,730
    16

    Su

    AUG

  • DTW–SCL, 08/17/26 – 08/24/26: From $1,735
    17

    Mo

  • DTW–SCL, 08/18/26 – 08/25/26: From $1,735
    18

    Tu

  • DTW–SCL, 08/19/26 – 08/26/26: From $1,735
    19

    We

  • DTW–SCL, 08/20/26 – 08/27/26: From $1,730
    20

    Th

  • DTW–SCL, 08/21/26 – 08/28/26: From $1,735
    21

    Fr

  • DTW–SCL, 08/22/26 – 08/29/26: From $1,745
    22

    Sa

  • DTW–SCL, 08/23/26 – 08/30/26: From $1,635
    23

    Su

  • DTW–SCL, 08/24/26 – 08/31/26: From $1,635
    24

    Mo

  • DTW–SCL, 08/25/26 – 09/01/26: From $1,635
    25

    Tu

  • DTW–SCL, 08/26/26 – 09/02/26: From $1,635
    26

    We

  • DTW–SCL, 08/27/26 – 09/03/26: From $1,630
    27

    Th

  • DTW–SCL, 08/28/26 – 09/04/26: From $1,630
    28

    Fr

  • DTW–SCL, 08/29/26 – 09/05/26: From $1,695
    29

    Sa

  • DTW–SCL, 08/30/26 – 09/06/26: From $1,700
    30

    Su

  • DTW–SCL, 08/31/26 – 09/07/26: From $1,933
    31

    Mo

  • DTW–SCL, 09/01/26 – 09/08/26: From $1,600
    01

    Tu

    SEP

  • DTW–SCL, 09/02/26 – 09/09/26: From $1,933
    02

    We

  • DTW–SCL, 09/03/26 – 09/10/26: From $1,613
    03

    Th

  • DTW–SCL, 09/04/26 – 09/11/26: From $1,600
    04

    Fr

  • DTW–SCL, 09/05/26 – 09/12/26: From $1,650
    05

    Sa

  • DTW–SCL, 09/06/26 – 09/13/26: From $1,550
    06

    Su

  • DTW–SCL, 09/07/26 – 09/14/26: From $1,550
    07

    Mo

  • DTW–SCL, 09/08/26 – 09/15/26: From $1,550
    08

    Tu

  • DTW–SCL, 09/09/26 – 09/16/26: From $1,550
    09

    We

  • DTW–SCL, 09/10/26 – 09/17/26: From $1,550
    10

    Th

  • DTW–SCL, 09/11/26 – 09/18/26: From $1,550
    11

    Fr

  • DTW–SCL, 09/12/26 – 09/19/26: From $1,600
    12

    Sa

  • DTW–SCL, 09/13/26 – 09/20/26: From $1,500
    13

    Su

  • DTW–SCL, 09/14/26 – 09/21/26: From $1,500
    14

    Mo

  • DTW–SCL, 09/15/26 – 09/22/26: From $1,500
    15

    Tu

    • range$1,500-$1,933

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Detroit to Santiago flights

    $
    keyboard_arrow_down

    Detroit (DTW)to

    Santiago (SCL)
    12/08/26 - 12/15/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/10/26 - 12/17/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/07/26 - 12/14/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/06/26 - 12/13/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/09/26 - 12/16/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/03/26 - 12/10/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    Detroit (DTW)to

    Santiago (SCL)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $1,281Fare subject to changes
    Updated: 4 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Detroit to Santiago

    Looking for lower fares on your trip from Detroit to Santiago? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Detroit to Santiago