American Airlines flights from San Francisco to Santiago

Recent searches for flights from San Francisco to Santiago

Aug 2026
From$935*
Updated: 1 hour ago
Round tripIEconomy
Sep 2026
From$920*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$905*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $935
cmp-daily-histogram-bars-legend-max-price-aria-label $1.8K
Displaying fares for August-2026
  • SFO–SCL, 08/16/26 – 08/23/26: From $1,143
    16

    Su

    AUG

  • SFO–SCL, 08/17/26 – 08/24/26: From $1,115
    17

    Mo

  • SFO–SCL, 08/18/26 – 08/25/26: From $935
    18

    Tu

  • SFO–SCL, 08/19/26 – 08/26/26: From $935
    19

    We

  • SFO–SCL, 08/20/26 – 08/27/26: From $935
    20

    Th

  • SFO–SCL, 08/21/26 – 08/28/26: From $1,275
    21

    Fr

  • SFO–SCL, 08/22/26 – 08/29/26: From $1,115
    22

    Sa

  • SFO–SCL, 08/23/26 – 08/30/26: From $935
    23

    Su

  • SFO–SCL, 08/24/26 – 08/31/26: From $935
    24

    Mo

  • SFO–SCL, 08/25/26 – 09/01/26: From $935
    25

    Tu

  • SFO–SCL, 08/26/26 – 09/02/26: From $1,120
    26

    We

  • SFO–SCL, 08/27/26 – 09/03/26: From $1,330
    27

    Th

  • SFO–SCL, 08/28/26 – 09/17/26: From $935
    28

    Fr

  • SFO–SCL, 08/29/26 – 09/05/26: From $1,025
    29

    Sa

  • SFO–SCL, 08/30/26 – 09/06/26: From $1,330
    30

    Su

  • SFO–SCL, 08/31/26 – 09/07/26: From $1,834
    31

    Mo

  • SFO–SCL, 09/01/26 – 09/08/26: From $1,014
    01

    Tu

    SEP

  • SFO–SCL, 09/02/26 – 09/09/26: From $1,834
    02

    We

  • SFO–SCL, 09/03/26 – 09/10/26: From $1,510
    03

    Th

  • SFO–SCL, 09/04/26 – 09/11/26: From $1,420
    04

    Fr

  • SFO–SCL, 09/05/26 – 09/12/26: From $1,497
    05

    Sa

  • SFO–SCL, 09/06/26 – 09/13/26: From $1,180
    06

    Su

  • SFO–SCL, 09/07/26 – 09/14/26: From $940
    07

    Mo

  • SFO–SCL, 09/08/26 – 09/15/26: From $935
    08

    Tu

  • SFO–SCL, 09/09/26 – 09/16/26: From $935
    09

    We

  • SFO–SCL, 09/10/26 – 09/17/26: From $940
    10

    Th

  • SFO–SCL, 09/11/26 – 09/18/26: From $1,120
    11

    Fr

  • SFO–SCL, 09/12/26 – 09/19/26: From $940
    12

    Sa

  • SFO–SCL, 09/13/26 – 09/20/26: From $1,115
    13

    Su

  • SFO–SCL, 09/14/26 – 09/21/26: From $935
    14

    Mo

  • SFO–SCL, 09/15/26 – 09/22/26: From $940
    15

    Tu

    • range$935-$1,834

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on San Francisco to Santiago flights

    $
    keyboard_arrow_down

    San Francisco (SFO)to

    Santiago (SCL)
    12/03/26 - 12/10/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    12/06/26 - 12/13/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    11/26/26 - 12/03/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    12/05/26 - 12/12/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    San Francisco (SFO)to

    Santiago (SCL)
    11/16/26 - 11/23/26

    Round trip

    Economy

    from
    $752Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from San Francisco to Santiago

    Looking for lower fares on your trip from San Francisco to Santiago? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from San Francisco to Santiago